Taxus : The Genus Taxus (Medicinal and Aromatic Plants - Industrial Profiles)

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Taxus : The Genus Taxus (Medicinal and Aromatic Plants - Industrial Profiles)

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  • 製本 Hardcover:ハードカバー版/ページ数 386 p.
  • 言語 ENG,ENG
  • 商品コード 9780415298377
  • DDC分類 615.3252

Full Description


Taxol, originally derived from the North American Yew tree in 1971, is well-known worldwide as a powerful anticancer agent. Mechanistically, it has a unique microtubule stabilizing activity, and was clinically developed as a therapeutic agent in the treatment of breast and ovarian cancers at the National Cancer Institute, Washington D.C., USA.In this volume, the authors provide an authoritative account of the taxoids. it covers their production and biosynthesis - from commercial cultivation to plant tissue culture methods - describes taxoid chemistry, the analytical methods for identifying their structure and the pharmacological and pre-clinical aspects important in investigating their therapeutic actions.It presents a thorough review of the scientific literature, including data from scientists currently engaged in taxoid research, and will be of significant value to researchers and others who wish to gain a practical perspective on taxoid research and development.

Table of Contents

        List of contributors                       ix
Preface to the series xi
Preface xiii
Introduction 1 (18)
Hideji Itokawa
Biosynthesis of taxoids 19 (16)
Ushio Sankawa
Hideji Itokawa
Taxiods occurring in the genus Taxus 35 (44)
Hideji Itokawa
Physical methods for identification of the 79 (55)
structures of taxoids
Masayoshi Oyama
Hideji Itokawa
Plant tissue culture of taxoids 134 (17)
Koichi Takeya
The commercial cultivation of Taxus species 151 (28)
and production of taxoids
Yoshinari Kikuchi
Mitsuyoshi Yatagai
Analytical aspects of taxoids 179 (34)
Mutsuo Kozuka
Susan Morris-Natschke
Kuo-Hsiung Lee
Chemistry of taxol and related taxoids 213 (32)
Hui-Kang Wang
Hironori Ohtsu
Hideji Itokawa
Total synthesis of taxoids 245 (53)
Zhiyan Xiao
Hideji Itokawa
Kuo-Hsiung Lee
Structure-activity relationships of taxoids 298 (89)
Xihong Wang
Hideji Itokawa
Kuo-Hsiung Lee
Preclinical and clinical studies of the 387 (49)
taxanes
David T. Brown
Paclitaxel content of yews in Ireland 436 (7)
Ingrid Hook
Dairine Dempsey
Name index 443 (6)
Subject index 449