プロドラッグ（全２巻） Prodrugs : Challenges and Rewards (Biotechnology : Pharmaceutical Aspects)

Stella, V. (EDT)/ Borchardt, Ronald (EDT)/ Hageman, M. (et al., EDT)

Springer（2007/04発売）

• 製本 Hardcover:ハードカバー版／ページ数 1,470 p.／サイズ 891 illus.
• 言語 ENG
• 商品コード 9780387497822

基本説明

プロドラッグの概念、薬の送達や製剤の問題解決の応用例を紹介する。
Contents - A Case for Prodrugs.- Problems Addressable by Prodrugs.- Prodrug Approaches to Enhancing the Oral Delivery of Poorly Permeable Drugs.- Topical Delivery Using Prodrugs.- Prodrug Approaches to Ophthalmic Drug Delivery.- Oral Delivery.- Prodrugs and Parenteral Drug Delivery.- Poly (ethylene glycol) Prodrugs: Altered Pharmacokinetics and Pharmacodynamics.- Prodrugs to Reduce Presystemic Metabolism.- Small Molecules.- Controlled Release – Macromolecular Prodrugs.- Proenzymes.- Targeting: Theoretical and Computational Models.- Cancer—Small Molecules.- Monoclonal Antibody Drug Conjugates for Cancer Therapy.- Antibody-Directed Enzyme Prodrug Therapy (ADEPT); and more.

Full Description

There are a number of small pharmaceutical/biotech companies dedicated to using prodrugs for the delivery of older but problematic drugs as well as to developing broad-based prodrug technologies for application to new and future drugs.