プロドラッグ（全２巻） Prodrugs : Challenges and Rewards (Biotechnology : Pharmaceutical Aspects)

Stella, V. (EDT)/ Borchardt, Ronald (EDT)/ Hageman, M. (et al., EDT)

Springer（2007/04発売）

• 製本 Hardcover:ハードカバー版／ページ数 1,470 p.／サイズ 891 illus.
• 言語 ENG
• 商品コード 9780387497822

基本説明

プロドラッグの概念、薬の送達や製剤の問題解決の応用例を紹介する。
Contents - A Case for Prodrugs.- Problems Addressable by Prodrugs.- Prodrug Approaches to Enhancing the Oral Delivery of Poorly Permeable Drugs.- Topical Delivery Using Prodrugs.- Prodrug Approaches to Ophthalmic Drug Delivery.- Oral Delivery.- Prodrugs and Parenteral Drug Delivery.- Poly (ethylene glycol) Prodrugs: Altered Pharmacokinetics and Pharmacodynamics.- Prodrugs to Reduce Presystemic Metabolism.- Small Molecules.- Controlled Release – Macromolecular Prodrugs.- Proenzymes.- Targeting: Theoretical and Computational Models.- Cancer—Small Molecules.- Monoclonal Antibody Drug Conjugates for Cancer Therapy.- Antibody-Directed Enzyme Prodrug Therapy (ADEPT); and more.

Full Description

Prodrugs are substances administered in an inactive form that is then metabolized in the body in vivo into the active compound. The rationale behind administering prodrugs is to optimize absorption, distribution, metabolism, and excretion of these drugs. Since first described in the 1950s, prodrugs continue to be a fertile area of research. There are a number of small pharmaceutical/biotech companies dedicated to using prodrugs for the delivery of older but problematic drugs as well as to developing broad-based prodrug technologies for application to new and future drugs. These volumes represent a comprehensive guide to prodrugs and will guide the reader through the current status of the prodrug concept and its many applications and to highlight its many successes in overcoming formulation and delivery of problematic drugs.