Hypothalamus : Brainstem Interactions in Homeostasis

Hypothalamus : Brainstem Interactions in Homeostasis

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  • 製本 Hardcover:ハードカバー版/ページ数 350 p.
  • 言語 ENG
  • 商品コード 9780387290836
  • DDC分類 616.8

Full Description

In recent years, there has been a resurgence of research interest in the role of the hypothalamus in a variety of regulatory and behavioral functions, from feeding and energy homeostasis to circadian rhythms, thermoregulation and blood pressure control. Nearly every homeostatic function influenced by the hypothalamus is subject to a dysregulation that becomes manifest in a disease process. Elucidating the neuropharmacology of the hypothalamic-brainstem circuits that play such a significant role in homeostatic regulation can contribute to the design of novel therapeutic approaches. In assembling the most recent knowledge about the structural and functional organization of hypothalamic-brainstem autonomic pathways regulating homeostasis and reproduction, this book provides a unique opportunity to appreciate the multifaceted role of hypothalamic neural circuits in maintaining homeostasis, to understand the critical role played by hypothalamic-brainstem interactions and to recognize the many parallels in organization and occurrences of cross-talk among the hypothalamic regulatory systems.

Contents

Hypothalamus-brainstem pathways.- Hypothalamic projections to brainstem nuclei.- Hypothalamic peptidergic inputs to the brainstemFluid and blood pressure regulation.- Hypothalamic - brainstem pathways in the modulation of baroreceptor reflex function.- Median preoptic, Paraventricular nucleus ? osmotic regulation, Ang II, renal sympathetic, fluid balance.- Paraventricular nucleus ? brainstem autonomic mechanisms in heart failureStress responses.- Dorsomedial hypothalamus ? pons/raphe in heart rate and defense response.- Dorsomedial hypothalamus ? brainstem in the regulation of ACTH releaseTemperature regulation.- Preoptic and dorsomedial hypothalamus ? brainstem in thermogenesis.- Hypothalamus ? brainstem in cutaneous vasoconstriction.- Posterior hypothalamus ? brainstem in shiveringEnergy homeostasis.- Arcuate ? paraventricular ? lateral hypothalamus interactions with brainstem circuits in regulation of food intake.- Hypothalamus ? nucleus of the tractus solitarius in satiety/appetite.- Hypothalamus ? brainstem influences on blood glucose.- Hypothalamus ? brainstem in energy expenditureRegulation of pelvic organs.- Preoptic hypothalamus ? Barrington?s in micturition.- Preoptic hypothalamus ? raphe in reproductionCircadian and sleep regulation.- Dorsomedial hypothalamus ? brainstem in circadian rhythms.- Lateral hypothalamus (orexin) ? brainstem in sleep regulation.- Hypothalamus ? brainstem in pineal (melatonin) regulationRespiratory regulation.- Hypothalamic - brainstem pathways in the control of respiration.- Hypothalamic - brainstem pathways in the modulation of chemoreceptor reflex function

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