Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics : Homogeneous and Heterogeneous Approaches (Interdisciplinary Applied Mathematics Vol.30) （2006. XVI, 411 p. w. 118 figs.）

Macheras, Panos/ Iliadis, Athanassios

SPRINGER, BERLIN（2006発売）

• ページ数 430 p.／サイズ 118 illus.
• 言語 ENG
• 商品コード 9780387281780

Full Description

This book presents a novel modeling approach to biopharamceutics, pharmacokinetics and pharmacodynamic phenomena. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. Throughout, many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods.

Contents

Basic Concepts.- The Geometry of Nature.- Diffusion and Kinetics.- Nonlinear Dynamics.- Modeling in Biopharmaceutics.- Drug Release.- Drug Dissolution.- Oral Drug Absorption.- Modeling in Pharmacokinetics.- Empirical Models.- Deterministic Compartmental Models.- Stochastic Compartmental Models.- Modeling in Pharmacodynamics.- Classical Pharmacodynamics.- Nonclassical Pharmacodynamics.