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Full Description
The Most Comprehensive, State-of-the-Art Book on Using Gene and Cell Therapy in Clinical Medicine Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, Fifth Edition presents extensive background and basic information, state-of-the-art technologies, important achievements, and lingering challenges in the fields of gene and cell therapies. The fifth edition of this bestseller continues to provide the most comprehensive coverage of these fields in one volume. Some chapters have expanded introductions, making the book even more suitable for classroom use. This edition also offers more material on the contributors' research efforts as well as current technologies, disease targets, and clinical applications.
Divided into four sections, the book covers:
Delivery systems and therapeutic strategies
Other therapeutic strategies, including technologies that knock down gene expression
Gene expression, regulation, and detection
Gene and cell therapies, disease targets, clinical trials, and regulatory issues
Accessible to a broad audience, including students, scientists, physicians, and lay people, this book provides readers with up-to-date, interdisciplinary knowledge and tools to tackle the evolving areas of gene therapy, cell therapy, and tissue engineering. From introductory information to state-of-the-art technologies and concepts, the book helps readers understand vector design and construction, delivery systems, therapeutic strategies, gene expression and detection, disease targets, clinical applications and trials, cell-based therapies, novel imaging systems, gene regulation, and regulatory affairs.
Contents
SECTION I: Gene Therapy
Chapter 1 Biology and Immunology of Recombinant Adeno-Associated Viral Vectors in Gene Therapy
Chapter 2 Alphavirus Vectors in Gene Therapy and Neuroscience
Chapter 3 Gene Electrotransfer
Chapter 4 Evolution of Polyplexes: Refining Structural Motifs Required for Nucleic Acid Delivery
Chapter 5 Therapeutic Applications of Morpholino Oligonucleotides
Chapter 6 Nonviral Genome Modification Strategies for Gene Therapy: Transposon, Integrase, and Nuclease Systems
Chapter 7 Complex In Vitro Models and Their Application in Gene Editing Technologies
Chapter 8 Gene Therapy for Vision Disorders
Chapter 9 Gene Therapy for Alzheimer's Disease
SECTION II: Cell Therapies
Chapter 10 Therapies with Adipose Tissue-Derived Stem/Stromal Cells
Chapter 11 Placenta-Derived Stem Cells and Their Therapeutic Applications
Chapter 12 Cell Based Therapies from Umbilical Cord Blood
Chapter 13 Cell Therapies for the Treatment of Inborn Metabolic Errors
Chapter 14 Cell Therapies for Gastro-Intestinal Disease
Chapter 15 Cell Therapies for Genitourinary Disorders
Chapter 16 Translating Stem Cell-Derived Extracellular Vesicle Therapy for Brain Disorders
SECTION III: Cell and Gene Therapy
Chapter 17 CARtalysts of Change: CAR T Cells at the Intersection of Engineering and Clinical Practice
Chapter 18 Prenatal Cell and Gene Therapy for Genetic Disorders
Chapter 19 Cell and Gene Therapies for Cardiovascular Disease
Chapter 20 Monitoring Gene and Cell Therapies in Living Subjects with Molecular Imaging Technologies
![Iwein : [Urtext und Übersetzung] （2. Aufl. 1974. 243 S. 230 mm）](../images/goods/ar/work/imgdatak/31100/3110048604.jpg)
