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Full Description
The Most Comprehensive, State-of-the-Art Book on Using Gene and Cell Therapy in Clinical Medicine Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, Fifth Edition presents extensive background and basic information, state-of-the-art technologies, important achievements, and lingering challenges in the fields of gene and cell therapies. The fifth edition of this bestseller continues to provide the most comprehensive coverage of these fields in one volume. Some chapters have expanded introductions, making the book even more suitable for classroom use. This edition also offers more material on the contributors' research efforts as well as current technologies, disease targets, and clinical applications.
Divided into four sections, the book covers:
Delivery systems and therapeutic strategies
Other therapeutic strategies, including technologies that knock down gene expression
Gene expression, regulation, and detection
Gene and cell therapies, disease targets, clinical trials, and regulatory issues
Accessible to a broad audience, including students, scientists, physicians, and lay people, this book provides readers with up-to-date, interdisciplinary knowledge and tools to tackle the evolving areas of gene therapy, cell therapy, and tissue engineering. From introductory information to state-of-the-art technologies and concepts, the book helps readers understand vector design and construction, delivery systems, therapeutic strategies, gene expression and detection, disease targets, clinical applications and trials, cell-based therapies, novel imaging systems, gene regulation, and regulatory affairs.
Contents
Lentiviral Vectors: Design and Applications. Adenovirus-Vector-Mediated Gene Delivery: Barriers and Chemical Vector Modifications. Helper-Dependent Adenoviral Vectors for Gene Therapy. Vaccinia Viral Vectors for Vaccines and Oncolytic Virotherapy. Oncolytic Measles Virus-Based Delivery Systems. Baculovirus: A High-Capacity Vector for Versatile Gene Transfer. Redox-Responsive Polymer-Based Gene Delivery Systems. Dendrimers, Dendrigrafts, and Their Conjugations as Delivery Vectors in Gene Therapy. Optimization of Nonviral Gene Therapeutics Using Bilamellar Invaginated Vesicles. Magnetofection: Using Magnetic Particles and Magnetic Force to Enhance and Target Nucleic Acid Delivery. Pressurized Transvenous-Retrograde Extremity Perfusion. Oncolytic Viruses for Treatment of Cancer. Baculovirus as a Gene Delivery Vector for Bone and Cartilage Tissue Engineering. Bacteria as Gene Therapy Vectors for Cancer. New Advances in Cell-Based Drug and Gene Delivery Systems. Antisense Oligonucleotide-Based Therapeutics. Development of RNAi Therapeutics. Therapeutic Potential of microRNAs. Deliberate Regulation of Therapeutic Transgenes: Recent Advances in System Development and Uses. DNA Vaccines. FANG: bi-shRNAifurin and GMCSF DNA-Augmented Autologous Tumor Cell Vaccine: Clinical Results. Biology and Immunology of Recombinant Adeno-Associated Viral Vectors in Gene Therapy. Alphavirus Vectors in Gene Therapy and Neuroscience. Gene Electrotransfer. Evolution of Polyplexes: Refining Structural Motifs Required for Nucleic Acid Delivery. Therapeutic Applications of Morpholino Oligonucleotides. Nonviral Genome Modification Strategies for Gene Therapy: Transposon, Integrase, and Nuclease Systems. Complex In Vitro Models and Their Application in Gene Editing Technologies. Gene Therapy for Hematopoietic Disorders. Gene Therapy for Vision Disorders. Molecular Therapy for Type 1 and Type 2 Diabetes. Alipogene Tiparvovec: Gene Therapy for Familial Lipoprotein Lipase Deficiency. Gene Therapy for Neurological Diseases. Gene Therapy for Alzheimer's Disease. Gene Therapy for the Treatment of Cancer: From Laboratory to Bedside. Gene Therapy for the Treatment of Lung Cancer. RNA Interference-Based Gene Therapy Strategies for the Treatment of HIV Infection. Pluripotent Stem Cells and Their Therapeutic Applications. Directing Pluripotent Human Embryonic Stem Cells toward Lineage-Specific Cell Therapy Derivatives for Regenerative Medicine. Therapies with Adipose Tissue-Derived Stem/Stromal Cells. Placenta-Derived Stem Cells and Their Therapeutic Applications. Cell Based Therapies from Umbilical Cord Blood. Cell Therapies for the Treatment of Inborn Metabolic Errors. Cell Therapies for Lung Disease. Cell Therapies for Gastro-Intestinal Disease. Cell Therapies for Genitourinary Disorders. Cell Therapy for the Creation of Cartilage and Related Clinical Trials (online only). Translating Stem Cell-Derived Extracellular Vesicle Therapy for Brain Disorders. CARtalysts of Change: CAR T Cells at the Intersection of Engineering and Clinical Practice. Gene and Cell Therapies for Muscular Dystrophies. Prenatal Cell and Gene Therapy for Genetic Disorders. Cell and Gene Therapies for Cardiovascular Disease. Cell and Gene Therapies for the Treatment of Hearing Disorders. Cutaneous Cell- and Gene-Based Therapies for Inherited and Acquired Skin Disorders. Monitoring Gene and Cell Therapies in Living Subjects with Molecular Imaging Technologies.
