Full Description
The application of molecular biologic methods, recognition of neurogenic inflammatory processes, and utilization of genetic knockout animals are just some of the advances in toxicology of the upper airways in recent years. Toxicology of the Nose and Upper Airways presents a culmination of knowledge gained as a result of both human and experimental animal studies over the past decade. With contributions from internationally recognized leaders in the fields of experimental toxicology, respiratory medicine, otolaryngology, allergy, and sensory science, this volume:
Examines the effect of selected pollutants on the upper airways of both humans and experimental animals—emphasizing mechanistic issues in the process
Discusses epidemiologic findings from populations exposed occupationally or environmentally, comparing and contrasting alternative risk assessment approaches
Features clear chapter organization with sections on structure and function, dosimetry and toxicokinetics, functional and pathologic responses and their measurement, responses to specific agents, risk assessment, and special topics
This volume is an essential reference for pharmacologists and toxicologists concerned with the nose and upper airway, as well as clinicians, risk assessors, and sensory scientists.
Contents
Structure & function in the upper airway
Functional anatomy of the upper airway in experimental animals
Functional anatomy of the upper airway in humans
Functional neuroanatomy of the upper airway in experimental animals
Functional neuroanatomy of the human upper airway
Mucosal enzymology of the upper airway. Dosimetry & Toxicokinetics of Nasal Exposure
Upper airway dosimetry of gases, vapors and particulate matter in experimental animals
Upper airway dosimetry of gases and vapors in humans
Upper airway dosimetry of particulate matter in humans. Functional & Pathologic Responses and Their Measurement
Exposure and recording systems in human studies
Biomarkers of nasal toxicity in experimental animals
Biomarkers of nasal toxicity in humans
Nasal reflexes - including alterations in respiratory behavior - in experimental animals
Nasal chemosensory irritation in humans
Nasal reflexes in humans
Olfactory toxicity in humans and experimental animals
Inflammatory conditions of the nose and paranasal sinuses in experimental animals
Inflammatory conditions of the nose and paranasal sinuses in humans
Chronic tissue changes and carcinogenesis in the upper airway. Responses to Specific Agents
Second hand tobacco smoke exposure in humans
Chlorine exposure in humans and experimental animals
Hydrogen sulfide exposure in experimental animals
Sulfur dioxide exposure in humans
Exposure to volatile organic compounds in humans. Risk Assessment and Special Topics
Benchmark dose and noncancer risk assessment for the upper airways
Physico-chemical modeling of sensory irritation in humans and experimental animals
Effect of allergic inflammation on irritant responsiveness in the upper airwa
