Full Description
First Published in 1992, since its discovery, a substantial body of information has been amassed concerning the functions of parathyroid hormone-related protein (PTHrP) in normal and malignant states. This book provides a state-of-the-art discussion of the major aspects of PTHrP biology and pathophysiology, in addition to presenting a historical perspective and discussions on the molecular biology of PTHrP, its mechanism of action, bioassays and radioimmunoassays, and its role in normal physiology. The book will be a primary resource for physicians interested in the clinical aspects of paraneoplastic hypercalcemia and mineral metabolic disorders. It will also serve as a primary resource for basic scientists in skeletal and renal physiology, tumor biology, and hormone action.
Contents
1. Identification of the Parathyroid Hormone-Related Peptide. 2. Molecular Biology of Parathyroid Hormone-Like Peptide. 3. Expression and Regulation of the Parathyroid Hormone-Related Protein Gene in Tumors and Normal Tissues. 4. Measurement of PTH-Related Protein and the Role of PTH-Related Protein in Malignancy-Associated Hypercalcemia. 5. Molecular Mechanism of Action of PTHrP. 6. Role of PTHrP Fetal and Neonatal Physiology. Index
