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Full Description
Molecular Biology of B Cells, Third Edition provides a comprehensive reference on how B cells are generated, selected, activated, and engaged in antibody production. These developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. The book offers an integrated view of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. This new edition provides updated research on B cell development and function, the use of therapeutic antibodies in cancer and infectious disease, and more. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, this updated release is a definitive resource, vital for researchers across molecular biology, immunology, and genetics.
Contents
1. The Structure and Regulation of the Immunoglobulin Loci
Joseph S. Lucas, Cornelis Murre, Ann J. Feeney and Roy Riblet
2. The Mechanism, Regulation and Evolution of V(D)J Recombination
David G. Schatz, Yiwen Zhang, Jianxiong Xiao, Shan Zha, Yu Zhang and Frederick W. Alt
3. The Origin of V(D)J Diversification
Ellen Hsu and Susanna M. Lewis
4. The Variable Lymphocyte Receptor B System of the Jawless Vertebrates
Thomas Boehm, Max D. Cooper, Masayuki Hirano, Sabyasachi Das, Ryo Morimoto and Jonathan P. Rast
5. Structure and Signalling Function of the B-Cell Antigen Receptor and Its Coreceptors
Michael Reth, Kathrin Klasener, Lars Nitschke and Michael R. Gold
6. Fc Receptors
Jeffrey V. Ravetch and Stylianos Bournazos
7. Transcriptional Regulation of Early B-Cell Development
Ashley P. Ng, Rhiannon Morris and Stephen L. Nutt
8. Relationship between B-Cell Populations, Development and Function of B-Cell Subsets
Eva Piano Mortari and Rita Carsetti
9. B-Cell Development to Immunity and Tolerance
Fritz Melchers, Mir-Farzin Mashreghi and Peter K. Jani
10. The Role of the BAFF and Lymphotoxin Pathways in B Cell Biology
Fabienne Mackay and Jennifer L. Gommerman
11. Mechanism and Regulation of Immunoglobulin Class Switch Recombination
Fei-Long Meng, Lekha Nair, Keith C. Fernandez, Uttiya Basu and Jayanta Chaudhuri
12. Somatic Hypermutation
Jana Ridani, Philip Barbulescu, Alberto Martin and Javier M. Di Noia
13. Molecular Mechanism of Activation-Induced Cytidine Deaminase
Nasim A. Begum, Maki Kobayashi, Hitoshi Nagaoka and Tasuku Honjo
14. Molecular Pathogenesis of B-Cell Lymphomas
Laura Pasqualucci, Pantaleo De Simone and Riccardo Dalla-Favera
15. Human Immunodeficiencies Caused by Inborn Errors of B-Cell Development or Function
Stuart G. Tangye, Jean-Laurent Casanova and Cindy S. Ma
16. Memory B Cells and Plasma Cells
Mairi Anne McGrath, Florian Weisel, Andreas Radbruch and Mark Shlomchik
17. Homoeostatic Versus Pathogenic Autoantibodies: Origin, Structure and Effector Functions
Yemil Atisha-Fregoso, Rita Pozovskiy, Shabirul Haque, Manami Watanabe, Yong-Rui Zou and Betty Diamond
18. Anti-Tumour Necrosis Factor and New Paradigms for Therapies Using Antibodies
Sergei A. Nedospasov, Marina S. Drutskaya and Andrey A. Kruglov
19. Therapeutic Targeting of B Cells and Plasma Cells with a Focus on Multiple Sclerosis and Other Autoimmune Conditions
Andreia C. Lino and Thomas Dorner
20. IMGT Immunoglobulin Repertoire
Analysis and Antibody Humanization Marie-Paule Lefranc
21. Mucosal Immunity to Bacteria and Immunoglobulin A Synthesis
Andrew J. Macpherson, Tim Rollenkse, Lucia M. Kato and Sidonia Fagarasan
22. B-Cell Metabolism
Julia Jellusova
