Full Description
Sinusoidal Cells in Liver Diseases: Role in their Pathophysiology, Diagnosis, and Treatment provides a state-of-the-art review on recent advances surrounding the role of liver sinusoidal cells (LSECs, HSCs, macrophages, and other non-parenchymal cells) in acute and chronic liver diseases. Coverage emphasizes disease pathophysiology, novel mechanisms, unmet clinical questions, development of biomarkers, and treatment opportunities. By focusing on the role of sinusoidal cells in human liver diseases, this reference provides a comprehensive overview of the role of sinusoidal cells in acute and chronic liver diseases, in its pathophysiology and mechanisms, and in the development of novel biomarkers and new therapeutics.
Cells of the liver vasculature play an essential role in the pathophysiology of acute and chronic liver diseases and are considered key therapeutic targets to treat most of human hepatopathies. Coverage in this reference includes the phenotypic changes occurring in liver vascular cells and how cells contribute to the development of microcirculatory dysfunction, fibrosis, inflammation, and liver failure.
Contents
Section 1 The liver sinusoid - General concepts
1. The unique architecture of the hepatic sinusoid
2. Sinusoidal cells interactions - from soluble factors to exosomes
3. Sinusoidal cells and liver immunology
4. Microscopic imaging of the hepatic sinusoid
5. The liver sinusoid at single cell level
6. Advanced models to study the liver sinusoid
7. Aging and the liver sinusoid
Section 2 The liver sinusoid in acute liver injury
8. Drug-induced liver injury
9. Ischemia-reperfusion injury and liver regeneration
10. Acute bacterial and viral infections
Section 3 The liver sinusoid in chronic liver disease
11. NAFLD and NASH
12. Chronic viral infection
13. Alcoholic liver disease
14. Portal hypertension
15. Liver fibrosis
16. Acute on chronic liver failure
17. Liver cancer
18. Cholestatic diseases
Section 4 The liver sinusoid in other vascular diseases
19. Portal vein thrombosis
20. Sinusoidal obstructive syndrome
21. Budd Chiari syndrome
Section 5 Liver sinusoidal cells in the diagnosis and treatment of liver diseases
22. Role of liver sinusoidal endothelial cells
23. Role of Kupffer cells and other immune cells
24. Role of hepatic stellate cells
