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Full Description
The Chemistry of Hyperpolarized Magnetic Resonance Probes, Volume Seven focuses on the chemical aspects of hyperpolarized NMR/MRI technology, with synthesis and characterizations of labeled compounds discussed from a practical point-of-view. A brief overview of the various hyperpolarization techniques are given, with the optimization of hyperpolarization conditions and the determination of critical parameters such as polarization level and T1 relaxation values described. A practical guide on the in vivo applications of hyperpolarized compounds in small animals is also included.
Contents
1. Hyperpolarized tracer design, synthesis and characterization
2. Optimization of hyperpolarized NMR signals in dissolution dynamic nuclear polarization
3. The chemistry of parahydrogen induced polarization (PHIP)
4. Beyond 13C-pyruvate: Biomedical applications with alternate hyperpolarized probes
5. Technical Considerations of MRI methods for validating DNP probes in small animals
