Full Description
Immunology of Recurrent Pregnancy Loss provides doctors and immunologists with the information they need to help couples who experience recurrent pregnancy losses. Sections cover unexplained infertility, repeated in vitro fertilization, embryo transfer failures, history of second or third trimester pregnancy losses of unknown cause, or pregnancy with a history of or active autoimmune and/or alloimmune disease. Reproductive failure (RF), including recurrent pregnancy losses (RPL) and repeated implantation failures (RIF) is rather a syndrome than a disease caused by multiple etiologies, such as anatomical, endocrine, genetic, infectious, immunological, thrombotic and unexplained etiologies, hence this book strives to present the latest information.
In 27 chapters, divided in 5 sections, the book introduces the current update of reproductive immunology topics in RF and provides systematic diagnostic guidelines, systemic and immune etiologies and therapeutic approaches.
Contents
Section 1. Introduction
Section 2. RPL of immune etiologies
1. Autoimmune etiologies focusing antiphospholipid antibody
2. ANA related conditions
3. Celiac disease and RPL/RIF
4. NK cell pathology and RF; NK cell level, NK cell cytotoxicity and KIR/HLA-C
5. Th cell pathology and RPL; TH1/Th2, Treg/Th17, and others
6. B cell pathology and RPL; B cell
7. Mast cell pathology and RPL
8. Endometrial pathology and RPL
9. Infectious diseases that can flare immune responses; Lyme's disease, COVID-19, etc.
10. Thrombophilic pathology and RPL
11. Alloimmune conditions (NAIT, Rh sensitization)
Section 3. Repeated implantation failures of immune etiologies
12. Autoimmune etiologies focusing antiphospholipid antibody
13. NK cell pathology and RIF
14. Th cell pathology and RIF
15. B cell pathology and RIF; Allergy, Asthma and infertility
16. Endometrial pathology and RIF
17. Thrombophilic condition and RIF
Section 4. Systemic immune etiologies for RIF/RPL
18. Ovarian pathology and RIF/RPL
19. Endometriosis and RIF/RPL
20. ART and RIF/RPL
21. Hormonal/metabolic diseases that can cause proinflammatory condition: autoimmune thyroiditis, PCOS, DM, vitamin D deficiency, and homocysteinemia
22. Stress induced immune flare in women with RF
Section 5. Treatment modalities
23. Immunotherapy
24. Anti-coagulant
25. Hormonal/metabolic
26. Reproductive supplements
27. Vitamins: Vitamin C, D, E, Folic acid, vitamin B12, selenium, zinc
28. Ovulation boost; DHEA, CoQ10, myoinositol, acaiberry, MACA, ALA, NAC, melatonin
29. Anti-inflammatory- LDN (low dose naltrexone), curcumin
30. Chinese medicine: Zishen Yutai pill, Shoutai pill
