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Full Description
Designer Microbial Cell Factories: Metabolic Engineering and Applications, the latest release in the Current Developments in Biotechnology and Bioengineering series, provides a detailed overview of the biotechnological approaches and strategies used to generate engineered microbes and to facilitate the acceleration, modulation and diversion of metabolic pathways to get desired output such as production of value-added compound or biodegradation of xenobiotic pollutant. The book also highlights applied aspects of designer microbes in fields as diverse as agriculture, pharmaceuticals and bioremediation.
Designer microbes generated through reprogramming the microbial cell factories (MCFs) provide an edge over their natural counterparts in terms of increased molecular diversity and selective chemistry. These bugs are becoming instrumental in several areas, including agriculture, environment and human health. Engineering microbes through directed evolution not only gives freedom from evolutionary constrains but also allow introduction of regulated and foreseeable functions into MCFs.
Contents
Section I: Technical Aspects of Metabolic Engineering
1. Metabolic engineering: Tools for rewiring of pathways and creation of value
2. Membrane Transport as Target for Metabolic Engineering
3. Analysis and Modeling Tools of Metabolic Flux
4. Equipped C1 chemical assimilation pathway in Engineering Escherichia coli
5. Microbial Tolerance in Metabolic Engineering
6. Application of proteomics and metabolomics in microbiology research
7. Recent approaches and tools of protein tailoring for metabolic engineering
8. Microbial metabolism of aromatic pollutants: High-throughput OMICS and metabolic engineering for efficient bioremediation
9. Microbial Consortium Engineering for the Improvement of Biochemical Production
Section II: Translational Aspects of Metabolic Engineering
10. Metabolic Engineering Strategies for Effective Utilization of Cellulosic Sugar(s) to Produce Value-added Products
11. Production of fine chemicals from renewable feedstocks through the engineering of artificial enzyme cascades
12. Metabolic engineering of microorganisms for the production of numerous value-added Products
13. Bioengineering in microbial production of bio-butanol from renewable resources
14. Engineered microorganisms for bioremediation
15. Agricultural applications of Engineered Microbes
16. Rhizosphere microbiome engineering
17. Genetically engineered microbes in micro-remediation of metals from contaminated sites
18. Biofuel production from renewable feedstocks: worldwide scenario and progress through metabolic engineering
19. Synthetic biology and the regulatory roadmap for the commercialization of designer microbes
