ゲノム安定性：ウイルスから人間的応用まで（第２版） Genome Stability : From Virus to Human Application (Translational Epigenetics) （2ND）

ゲノム安定性：ウイルスから人間的応用まで（第２版）<br>Genome Stability : From Virus to Human Application (Translational Epigenetics) （2ND）

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ゲノム安定性：ウイルスから人間的応用まで（第２版）
Genome Stability : From Virus to Human Application (Translational Epigenetics) （2ND）

Kovalchuk, Igor (EDT)/ Kovalchuk, Olga (EDT)

ウェブストア価格 ¥41,676（本体¥37,888）
Academic Press Inc（2021/07発売）
外貨定価 US$ 200.00
ポイント 378pt

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製本 Paperback:紙装版/ペーパーバック版／ページ数 760 p.
言語 ENG
商品コード 9780323856799
DDC分類 572.86459

Full Description

Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging.

This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability.

1. Genome stability: An evolutionary perspective

Part I Genome instability of viruses
2. Genetic instability of RNA viruses
3. Genome instability in DNA viruses

Part II Genome instability in bacteria and archaea
4. Genome instability in bacteria and archaea: Strategies for maintaining genome stability
5. Genome instability in bacteria: Causes and consequences
6. CRISPR - Bacterial immune system

Part III Genome stability of unicellular eukaryotes
7. From micronucleus to macronucleus: Programmed DNA rearrangement in ciliates is regulated by non-coding RNA molecules
8. Homologous recombination and nonhomologous end-joining repair in yeast

Part IV Genome stability in multicellular eukaryotes
9. Meiotic and mitotic recombination: First in flies
10. Genome stability in Drosophila: Mismatch repair and genome stability
11. Genome stability in Caenorhabditis elegans
12. Plant genome stability—General mechanisms
13. Genetic engineering in plants using CRISPRs

Part V Genome stability in mammals
14. Cell cycle control and DNA-damage signaling in mammals
15. The role of p53/p21/p16 in DNA damage signaling and DNA repair
16. Roles of RAD18 in DNA replication and post-replication repair (PRR)
17. Base excision repair and nucleotide excision repair
18. DNA mismatch repair in mammals
19. Repair of double-strand breaks by nonhomologous end joining; Its components and their function
20. Homologous recombination in mammalian cells: From molecular mechanisms to pathology
21. Telomere maintenance and genome stability
22. Chromatin, nuclear organization and genome stability in mammals
23. Role of DNA mthylation in genome stability
24. Non-coding RNAs in genome integrity

Part VI
Human diseases associated with genome instability
25. Human diseases associated with genome instability
26. Cancer and genomic instability
27. Epigenetic regulation of the cell cycle & DNA-repair in cancer
28. Genomic instability and aging: Causes and consequences
29. The DNA damage response and neurodegeneration: Highlighting the role of the nucleolus in genome (in)stability

Part VII Effect of environment on genome stability
30. Diet and nutrition
31. Chemical carcinogens and their effect on genome and epigenome stability
32. Modern sources of environmental ionizing radiation exposure and associated health consequences

Part VIII Bystander and transgenerational effects: Epigenetic perspective
33. Sins of fathers through a scientific lens: Transgenerational effects
34. Radiation and chemical induced genomic instability as a driver for environmental evolution
35. Transgenerational genome instability in plants
36. Methods for the detection of DNA damage
37. Conserved and divergent features of DNA repair. Future perspectives in genome stability research
38. Off-target effects in genome editing