Full Description
Standardizing Pharmacology: Assays and Hormones, Volume Two in the Discoveries in Pharmacology series, presents selected articles from historic discoveries that are enhanced with commentary from contemporary scholars who present discussions on the importance of each chapter, along with an updated bibliography on the subject and contributions from a Nobel Prize winner and other pioneers in pharmacology. Academic and industry researchers in pharmacology and medicine, as well as advanced students will find this series a useful teaching tool and launch to new discoveries.
Sections cover key discoveries in receptor theory, pharmacological methods and the development of hormone therapy, including J. Parascandola on the development of receptor theory, R.S. Yalow on radioimmunoassay, M. van Rossum and J.T L.A. Hurkmans on bioassays, M. Tausk on androgen therapy and C. Djerassi on oral contraceptives, with commentaries from experts such as T. Hökfelt and V.C. Jordan.
Contents
Section I. Redirected traffic: the history of drugs affecting haemodynamics
1. The control of blood pressure
Part 1 - The discovery of beta adrenoceptor blocking drugs
Part 2 - Peripheral anti-hypertensives: ganglion and adrenergic neurone-blocking agents
Section II. The discovery and application of hormones
2. The emergence of endocrinology
3. Sex hormones
Part 1 - Androgens and anabolic steroids
Part 2 - The biological history of the Pill
Part 3 - The chemical history of the Pill
Section III. Overcoming the body's defence system
4. Anti-inflammatory drugs
Part 1 - The proliferation of non-steroidal anti-inflammatory drugs (NSATDS)
Part 2 - The story of aspirin, H.O.J. Collier
5. The inhibition of allergic reactions
Part I - Histamine receptor antagonists
Part 2 - Asthma: a long and continuing story
Section IV. Assays and the molecular basis of drug action
6. A probe for the fine structures of the body
7. Isolated smooth muscle in pharmacology
Part 1 - The guts of the matter: contribution of studies on smooth muscle to discoveries in pharmacology
Part 2 - Bioassay: a pharmacological endeavour
8. Making visible the invisible (Recollections of the first experiences with the histochemical fluorescence method for visualization of tissue monoamines)
9. Receptors in pharmacology
Section V. History of chemotherapy
10. From dyes to drugs
11. The discovery of penicillin and cephalosporins
12. The antibiotic explosion
