Full Description
Glucagon-like peptide-1 receptor (GLP-1R) agonists, originally developed for type 2 diabetes patients and popularized by their ability to rapidly reduce body weight in patients with obesity, have recently received a lot of national attention. Repurposing GLP-1R agonists to treat some central nervous disorders is promising, but comparatively understudied. At a September 2024 workshop, the National Academies Forum on Neuroscience and Nervous System Disorders reviewed the current knowledge and research gaps about the mechanisms of action of GLP-1R agonists in the brain, and the evidence of their clinical efficacy for eating disorders, neurodegenerative diseases, substance use disorders, and pain.
Table of Contents
Front Matter
1 Introduction and Background
2 GLP-1 Mechanisms in the Brain
3 Learning from Those with Lived Experiences
4 Ingestive Behavior Disorders
5 Substance Use Disorder and Alcohol Use Disorder
6 Neurodegenerative Disorders and Other Emerging Areas
7 Real-World Evidence, Accessibility, and Health Equity
8 Workshop Reflections and Opportunities to Move Forward
Appendix A: References
Appendix B: Workshop Agenda
