Review of Texas Commission on Environmental Quality's Ethylene Oxide Development Support Document

National Academies Press（2025/07発売）

• 製本 Paperback:紙装版/ペーパーバック版／ページ数 74 p.
• 言語 ENG
• 商品コード 9780309731652

Full Description

Ethylene oxide is primarily produced in Texas and Louisiana with sites in Texas accounting for nearly half of all emitted ethylene oxide in the United States. Because ethylene oxide is emitted in Texas and has been determined by other agencies to be a carcinogen, the Texas Commission on Environmental Quality (TCEQ) undertook a carcinogenic dose-response assessment for use in TCEQ's remediation and air permitting programs. The TCEQ assessed the carcinogenic hazards of ethylene oxide and derived a chronic inhalation unit risk factor (URF) in its 2020 Ethylene Oxide Carcinogenic Dose-Response Assessment Development Support Document (TCEQ DSD).

As requested by TCEQ, the National Academies of Sciences, Engineering, and Medicine assembled an ad hoc committee to review the methods, results, and conclusions of the TCEQ DSD. The committee considered whether the conclusions are clearly presented, scientifically supported, and based on the best available scientific information. The report finds that the lack of application of systematic review methods, the exclusion of critical epidemiological data, the limitations in the modeling approach and use of unpublished validation data all contribute to a lack of confidence in TCEQ's risk assessment of ethylene oxide.

Table of Contents

Front Matter
Summary
1 Introduction
2 Hazard Identification
3 Dose-Response
References
Appendix A: Committee Biographies
Appendix B: Public Meeting Agenda