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Full Description
On October 17, 2014, spurred by incidents at U.S. government laboratories that raised serious biosafety concerns, the United States government launched a one-year deliberative process to address the continuing controversy surrounding so-called "gain-of-function" (GOF) research on respiratory pathogens with pandemic potential. The gain of function controversy began in late 2011 with the question of whether to publish the results of two experiments involving H5N1 avian influenza and continued to focus on certain research with highly pathogenic avian influenza over the next three years. The heart of the U.S. process is an evaluation of the potential risks and benefits of certain types of GOF experiments with influenza, SARS, and MERS viruses that would inform the development and adoption of a new U.S. Government policy governing the funding and conduct of GOF research.
Potential Risks and Benefits of Gain-of-Function Research is the summary of a two-day public symposia on GOF research. Convened in December 2014 by the Institute of Medicine and the National Research Council, the main focus of this event was to discuss principles important for, and key considerations in, the design of risk and benefit assessments of GOF research. Participants examined the underlying scientific and technical questions that are the source of current discussion and debate over GOF research involving pathogens with pandemic potential. This report is a record of the presentations and discussion of the meeting.
Table of Contents
Front Matter
1 Introduction
2 Assessing Risks and Benefits
3 Gain-of-Function Research: Background and Alternatives
4 Potential Benefits of Gain-of-Function Research
5 Potential Risks: Biosafety and Biosecurity
6 Policy Implications
References
Appendix A: Key Issues for Risk/Benefit Assessment for Gain-of-Function Research
Appendix B: Committee Biographies
Appendix C: Agenda
Appendix D: Speaker Biographies
Appendix E: List of Attendees
Appendix F: Acronym List
Contents
1 Front Matter; 2 1 Introduction; 3 2 Assessing Risks and Benefits; 4 3 Gain-of-Function Research: Background and Alternatives; 5 4 Potential Benefits of Gain-of-Function Research; 6 5 Potential Risks: Biosafety and Biosecurity; 7 6 Policy Implications; 8 References; 9 Appendix A: Key Issues for Risk/Benefit Assessment for Gain-of-Function Research; 10 Appendix B: Committee Biographies; 11 Appendix C: Agenda; 12 Appendix D: Speaker Biographies; 13 Appendix E: List of Attendees; 14 Appendix F: Acronym List
