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Full Description
Discover why the gut microbiome holds the keys to human health—and can change the way we understand, treat, and prevent disease.
"A detailed and scientifically rigorous survey . . . gives readers a clearer sense of the current state of medical knowledge." —The New York Review of Books
We are at the dawn of a new scientific revolution. Our understanding of how to treat and prevent diseases has been transformed by knowledge of the microbiome—the rich ecosystem of microorganisms in and on every human. In Gut Feelings, Alessio Fasano and Susie Flaherty show why we must go beyond the older, myopic view of microorganisms as our enemies to a broader understanding of the microbiome as a parallel civilization that we need to understand, respect, and engage with for the benefit of our own health.
Recent advances in understanding the microbiome and its role in human health dovetail with the development of personalized or "precision" medicine to create treatments and prevention programs targeted to the molecular imprint of an individual. Fasano and Flaherty explore the microbiome's part in such diseases as gut inflammatory disorders, obesity, neurological conditions, and cancer, and they explain new research in prebiotics, probiotics, synbiotics, and psychobiotics. They also discuss the microbiome and immune function, including a possible role in COVID-19 treatment.
By simultaneously expanding our perspective to encompass large datasets and multiple factors in human health, and narrowing our focus to identify the individual communities in the human microbiome, we will enlarge—and perhaps reinvent—our understanding of how to combat disease and maintain health.
Contents
Preface vii
I The Wisdom of a Microscopic Species
1 Evolutionary Biology Explains Bacterial
Adaptability 3
2 The Ancestral Microbiome 21
3 Early Factors Influencing the Microbiome 49
4 Cracking the Codes: From the Human Genome
to the Human Microbiome 81
5 Beyond Bacteria: Those Other "Omes" 103
6 The Microbiome Hypothesis: The Epigenetic Role
of the Microbiome 131
II The Microbiome's Role in Disease
7 The Microbiome and Gut Inflammatory
Disorders 165
8 The Microbiome and Obesity 187
9 The Microbiome and Autoimmunity 207
10 The Microbiome and Neurological and Behavioral
Disorders 237
11 The Microbiome and Environmental
Enteropathy 259
12 The Microbiome and Cancer 273
III Manipulating the Microbiome to Maintain Health
13 From Association to Causation: A New Approach
to Microbiome Composition and Function in
Disease Development 293
14 Preventive Medicine: Monitoring the Microbiome
for Disease Prediction and Interception 313
15 Treatments for Disease: Prebiotics, Probiotics,
Synbiotics, and Postbiotics 345
16 Microbiome Research in Gut-Brain Axis Diseases:
Psychobiotics 381
17 Artificial Intelligence, Synthetic Biology,
and the Microbiome 391
18 Maintaining a Resilient Microbiome through
Old Age 411
Epilogue: Why Studying Our Microbiome Is
Important for Our Future 425
Acknowledgments 443
Notes 445
