Full Description
AIDS at a Crossroads: How Antiretrovirals and Community Transformed the HIV Response chronicles the global HIV response through 2023, and the remarkable progress achieved toward epidemic control through innovation in biomedicine, the resolve of political leadership, and the steadfast commitment of communities on the frontlines of the HIV response. In this sequel to A Decade of HAART: The Development and Global Impact of Highly Active Antiretroviral Therapy (2008), leading voices in HIV medicine and global health chronicle how innovation in biomedicine, political will, and community leadership together transformed the trajectory of the HIV pandemic.
This timely volume captures the extraordinary progress toward epidemic control achieved through antiretroviral therapy, pre-exposure prophylaxis, and the validation of treatment as prevention, while candidly assessing the stigma, inequities, and policy failures that persist. Written during the COVID-19 pandemic, the book includes initial insights into the colliding pandemic's shock on health systems and how this novel public health threat tested the resilience of HIV responses everywhere. New political and fiscal shocks in 2025 - precipitated by the Trump administration's HIV and global health policy reversals and funding cuts - now threaten this progress in the United States and beyond.
Divided into three sections spanning biomedical innovation, country case studies, and strategies for achieving the goal of ending AIDS as a public health threat, AIDS at a Crossroads offers historical reflection on a public health success yet to be attained and an urgent warning that controlling, eliminating, and ultimately eradicating the HIV pandemic will depend as much on scientific breakthroughs as on sustained political will and community leadership.
Contents
Part 1. ART, PrEP, and the Continuum from Despair to a Decade of Action Chapter 1: José M. Zuniga: How Antiretroviral Therapy Turned the Tide of the HIV Pandemic Chapter 2: Myron S. Cohen, Theresa R. Gamble, and Marybeth McCauley: HPTN 052, the PARTNER Study, and the Dawn of Treatment as Prevention Chapter 3: Lee Fairlie, Faeezah Patel, and James McIntyre: The Impact of Option B+ PMTCT Implementation on Mothers Living with HIV Chapter 4: Christopher Duncombe: Challenges and Successes from a Decade and a Half of HIV Antiretroviral Therapy Chapter 5: Lao-Tzu Allan-Blitz and Kenneth H. Mayer: Pre-Exposure Prophylaxis for the Biomedical Prevention of HIV Infection Chapter 6: McLaughlin Angela, Julio S. G Montaner, and Jeffrey B Joy: Molecular Genetics: Using Phylogenetics to Enhance the HIV Response Chapter 7: Caroline Passaes and Asier Sáez-Cirión: From Elimination to Eradication: The Role of an HIV Vaccine and/or Cure Part 2. Action to Impact: Country Experiences with ART and PrEP Scale-Up Chapter 8: Irene Mukui, Francesca Odhiambo, Maurice Aluda, and Elizabeth Anne Bukusi: Country Review: Kenya Chapter 9: Yogan Pillay: Country Review: South Africa Chapter 10: Andrew D. Kambugu and Elly Tebasoboke Katabira: Country Review: Uganda Chapter 11: Jillian S. Y Lau, David W. J. Griffin, Mihiri P. Weerasuria, James H. McMahon, and Jennifer F. Hoy: Country Review: Australia Chapter 12: Zunyou Wu, Yan Zhao, and Jennifer M. McGoogan: Country Review: China Chapter 13: Praphan Phanuphak and Nittaya Phanuphak: Country Review: Thailand Chapter 14: Ana Roberta Pati Pascom, Nazle Mendonça Collaço Véras, Grace Perpétuo, Eduardo Malheiros, Gerson Fernando Pereira, and Adele S. Benzaken: Country Review: Brazil Chapter 15: J. Deas Van Onacker, E. G. Robin, K. François, V. Rouzier, N. Segaren, D. Jean François, M. M. Zevallos, S. Laguerre, N. Lamothe, F. Moise, M. M. Deschamps, B Liautaud, , J. W. Pape, P. Cremieux, F. Léandre, and S. Koenig: Country Review: Haiti Chapter 16: Leandro Cahn and Pedro Cahn: Country Review: Argentina Chapter 17: Taraz Samandari, Stacy Cohen, Kristen L. Hess, Steven R. Young, Janet Cleveland, Antigone Dempsey, and David W. Purcell: Country Review: United States Chapter 18: Peter Reiss: Country Review: The Netherlands Chapter 19: Matilde Sánchez-Conde, Maria J. Vivancos-Gallego, Javier Martínez-Sanz, and Santiago Moreno: Country Review: Spain Part 3. Challenges and Opportunities for Ending AIDS as a Public Health Threat Chapter 20: Matthew Weait: A Revitalized Human Rights and Legal Framework for Ending AIDS Chapter 21: Alan Whiteside: Financing the AIDS Response: Bilateral, Multilateral, and National Investments Chapter 22: Artur Acelino Francisco Luz Nunes Queiroz, Ricardo Baptista Leite, and Amish Laxmidas: Political Leadership for HIV Control: It Is Time to Unite for Action Chapter 23: José M. Zuniga, Sindhu Ravishankar, and Christopher Duncombe: Urbanizing Global Goals by Accelerating HIV Responses in Fast-Track Cities Chapter 24: Helena Nygren-Krug: Leveraging the HIV Response for the Achievement of Universal Health Coverage Chapter 25: José M. Zuniga: Conclusion
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