Full Description
Though the topics of 'pain' and 'headache' are obviously linked, these two research fields have in recent years developed at their own pace, often with scant attention paid to the other. By forging closer links between these fields, it should be possible to develop a deeper understanding of both the pain mechanisms associated with headache and a deeper understanding of pain itself. This book brings together researchers and clinicians from the forefront of these two disciplines to explore how the basic pain mechanisms relate to migraine and other forms of headache.
With cutting edge research from the frontiers of headache and pain research, the book will be essential for clinicians treating headache sufferers, providing answers to many of the commonly asked questions about the mechanisms of their headache. It will also be of interest to those pain researchers dealing with mechanisms related to headache and migraine.
Contents
SECTION I - MOLECULAR MECHANISMS IN INFLAMMATORY PAIN ; 1. Somatostatin and calcitonin gene-related peptide (CGRP) receptors in primary afferent neurons ; 2. The capsaicin receptor controls sensitivity and stimulated neuropeptide release in rodent meninges ; 3. Cytokines in inflammatory pain ; 4. Discussion summary: Molecular mechanisms in inflammatory pain ; SECTION II - NEUROBIOLOGY OF NEUROPATHIC PAIN ; 5. Mechanisms of inflammatory hyperalgesia ; 6. Translation of symptoms and signs into mechanisms in neuropathic pain ; 7. Neuropathic pain in the orofacial area ; 8. Discussion summary: Neurobiology of neuropathic pain ; SECTION III - THE TRIGEMINAL SYSTEM AND PAIN ; 9. Injury induced neuroplastic changes in trigeminal brainstem subnucleus caudalis: Trigeminal central sensitisation ; 10. Vascular and neuronal mechanisms related to the trigeminovascular system ; 11. Pathophysiological considerations in trigeminal neuralgia ; 12. Parasympathetic activation in experimental trigeminal pain ; 13. Trigeminovascular activation in cervicogenic headache ; 14. Hypertension-associated hypalgesia: an important mechanism in headache and other pains? ; 15. Central projections of sensory innervation of the rat superior sagittal sinus ; 16. Discussion summary: the trigeminal system and pain ; SECTION IV - ALLODYNIA AND HYPERALGESIA ; 17. Mechanisms of cutaneous hyperalgesia ; 18. Allodynia as a manifestation of migraine and other headaches ; 19. Muscular hyperalgesia in the head and orofacial area ; 20. Evidence for generalized muscular and cutaneous hyperalgesia in patients with chronic tension-type headache ; 21. Migrainous allodynia or triptan-induced allodynia? ; 22. Migraine facilitates high frequency of tension-type headache ; 23. Clinical assessment of hyperalgesia and allodynia in episodic migraine versus chronic migraine interictally and ictally ; 24. Discussion summary: Allodynia and hyperalgesia ; SECTION V - MODULATION OF PAIN ; 25. Mechanisms of pain facilitation systems: implications for medication overuse headache ; 26. Brainstem mechanisms of ongoing pain ; 27. How the brain talks to the spinal cord ; 28. Eletriptan in migraine: is pain-free response correlated with pain severity or time from headache onset to dosing? ; 29. Efficacy of eletriptan in improving functional impairment in migraine: results using a multidimensional functional and work productivity battery ; 30. CNS adverse events in patients treated with triptans: side effect or symptom? ; 31. Discussion summary: Modulation of pain ; SECTION VI - IMAGING OF PAIN AND ALLODYNIA ; 32. Cognitive control of emotion and pain in the human brain ; 33. Brain imaging of allodynia and hyperalgesia ; 34. Functional neuroimaging of primary headaches ; 35. Posterior cerebral hypoperfusion in migraine without aura ; 36. Brainstem and hypothalamic activation in spontaneous migraine attacks: a PET study ; 37. Discussion summary: Imaging of pain and allodynia
