Full Description
The Sixth Edition of Charney and Nestler's Neurobiology of Mental Illness builds on previous editions of the book and reflects the continuing progress in reintegrating psychiatry into the mainstream of modern biomedical science. This reintegration remains a work in progress, based on the unique complexity of the brain and its diseases. Yet, the research tools that are transforming other branches of medicine-epidemiology, genetics, epigenetics, molecular and cell biology, imaging, and medicinal chemistry, along with fundamental advances in the neurosciences that make it possible to decipher cell types and their larger circuits to an unprecedented degree, are now at long last transforming psychiatry.
Collectively, the 75 chapters in this newly renovated textbook describe the developments in genetics and in molecular, cellular, and systems neuroscience that are breaking new ground in the diagnosis, treatment, and prevention of disabling psychiatric disorders.
In this updated edition, Section 1 focuses on the major methodological approaches to studying the biological basis of mental illness. Sections 2 through 8 each focus on a major class of mental illness, including schizophrenia, bipolar disorder, depression, anxiety and trauma disorders, substance use disorders, neurodegenerative disorders, and childhood psychiatry disorders.
The final section is a collection of essays that address what can be expected over the next decade in terms of improving psychiatric diagnosis, achieving a true precision approach to treating mental illness, along with new avenues of medication and non-medication therapies in the offing.
Contents
SECTION 1: EMERGING AND ESTABLISHED TECHNOLOGIES
Section Editors: Eric J. Nestler and Kafui Dzirasa
1. Genetic Methodologies and Applications
Ben Neale
2. Multiscale Network Approaches to Decode the Complexity
of Common Human Diseases
Minghui Wang, Yiyuan Liu, Eric Schadt, and Bin Zhang
3. The Role of the Epigenome in Brain Development, Function, and Disease
Schahram Akbarian, John F. Fullard, Kiran Girdhar, and Panos Roussos
4. Methods for In Vivo Gene Manipulation
Lisa M. Monteggia and Wei Xu
5. Application of Stem Cells to Understanding
Psychiatric Disorders
Marcella, Burtele, Giorgia Quadrato, and Kristen Brennand
6. Optogenetics and Related Technologies for Psychiatric Disease Research: Current Status and Challenges
Lief E. Fenno and Karl Deisseroth
7. Methods for In Vivo Circuit Analysis
Micah Johnson, Yassine Filali, Radha Velamuri, Kafui Dzirasa, and Rainbo Hultman
8. Magnetic Resonance Methodologies
Hanzhang Lu and Peter A. Bandettini
9. PET Brain Imaging Methodologies
Ansel Hillmer, Kelly P. Cosgrove, and Richard E. Carson
10. Neuromodulation and Psychiatric Disorders
Andrew Smith, Martijn Figee, and Helen Mayberg
SECTION 2: SCHIZOPHRENIA
Section Editors: Judy Ford and Dan Mathalon
11. Diagnosis and Epidemiology of Schizophrenia
Julie Walsh-Messinger, Ariella Farzan Nikou, and Dolores Malaspina
12. Genetics of Schizophrenia
Sophie E. Legge, Antonio F. Pardiñas, and Michael C. O'Donovan
13. Neuroimaging and Circuit Mechanisms of Schizophrenia
Neil D. Woodward, Stephan Heckers, Dost Ongur, and Julia M. Sheffield
14. Animal and Cellular Models for the Study of Schizophrenia
Joshua A. Gordon
15. Neural and Circuit Mechanisms of Schizophrenia
Samuel J. Dienel and David A. Lewis
16. Glial-Immune Mechanisms of Schizophrenia: Animal and Human Studies
Kowsar Teymouri, Mahbod Ebrahimi, Jennie G. Pouget, and James L. Kennedy
17. Translational Models for Psychotic Symptoms
Phil Corlett
18. Current Treatments for Schizophrenia
Donald C. Goff
19. Novel Approaches for Treating Schizophrenia
Steve M. Paul and Alan Breier
SECTION 3: BIPOLAR DISORDER
Section Editor: Alex Charney
20. Diagnosis and Epidemiology of Bipolar Disorder
Kathleen R. Merikangas and Emma K. Stapp
21. Genetics of Bipolar Disorder
Dongjing Liu and Niamh Mullins
22. Neuroimaging and Circuit Mechanisms of Bipolar Disorder
E. Kale Edmiston, Michele A. Bertocci, Merage Ghane-Ezabadi, and Mary L. Phillips
23. Animal and Cellular Models for the Study of Bipolar Disorder
Michael J. McCarthy and Jared W. Young
24. Molecular and Cellular Mechanisms of Bipolar Disorder: Animal and Human Studies
Colleen A. McClung and Hilary P. Blumberg
25. Current Treatments for Bipolar Disorder
Nicole W. Simons and Alexander W. Charney
26. Novel Approaches for Treating Bipolar Disorder
Nefize Yalin, Allan H. Young, and Carlos A. Zarate, Jr.
SECTION 4: DEPRESSION
Section Editor: John Krystal
27. Diagnosis and Epidemiology of Depression
James W. Murrough
28. Genetics of Depression
Daniel Levey and Joel Gelernter
29. Neuroimaging and Circuit Mechanisms of Depression
Adrienne L. Romer, Michele A. Bertocci, Mary L. Phillips, and Diego A. Pizzagalli
30. Animal Models for the Study of Depression
Lyonna F. Parise, Astrid M. Cardona-Acosta, Eric M. Parise, and Carlos A. Bolaños-Guzmán
31. Neurotrophic Mechanisms of Depression: Animal and Human Studies
Lisa M. Monteggia
32. Glial-Immune Mechanisms of Depression: Animal and Human Studies
Georgia E. Hodes, Caroline Ménard, Madeline L. Pfau, and Scott J. Russo
33. Neuroendocrine Mechanisms of Depression: Animal and Human Studies
Elisabeth B. Binder and Jan M. Deussing
34. Current Treatments for Depression
Maurizio Fava and John Krystal
35. Novel Approaches for Treating Depression
Eric J. Nestler, Dennis S. Charney, John H. Krystal, and James W. Murrough
SECTION 5: ANXIETY AND TRAUMA-RELATED DISORDERS
Section Editor: Kerry J. Ressler
36. Diagnosis and Epidemiology of Anxiety, Obsessive-Compulsive, and Trauma- and Other Stress-Related Disorders
Murray B. Stein, Meghan E. Keough, and Peter P. Roy-Byrne
37. Genetics of Anxiety and Trauma-Related Disorders
Sarah E. Benstock and John M. Hettema
38. Neuroimaging and Circuit Mechanisms of Anxiety and Trauma-Related Disorders
Gregory A. Fonzo
39. Animal Models for the Study of Anxiety Disorders
Caroline Jia, Hao Li, and Kay Tye
40. Biological Mechanisms of Anxiety Disorders: Animal and Human Studies
Danielle M. Gerhard, Anfei Li, Francis S. Lee, and Heidi C. Meyer
41. Biological Mechanisms of Stress Resilience: Animal and Human Studies
Saren H. Seeley, Sarah Boukezzi, Jonathan DePierro, Dennis S. Charney, and Adriana Feder
42. Current Treatments for Anxiety and Trauma-Related Disorders
Kristin L. Szuhany, Benjamin Feldman, Matteo Malgaroli, and Naomi M. Simon
43. Novel Approaches for Treating Anxiety and Trauma-Related Disorders
Alfred P. Kaye, Sarah Jefferson, and John H. Krystal
SECTION 6: SUBSTANCE USE DISORDERS
Section Editors: Nora Volkow and Yavin Shaham
44. Epidemiology of Substance Use Disorders
Denise B. Kandel, Pamela C. Griesler, Mei-Chen Hu, Philippe A. Melas, Bradley T. Kerridge, and Bridget F. Grant
45. Genetics of Substance Use Disorders
David Goldman and Danielle Sambo
46. Neuroimaging and Circuit Mechanisms of Substance Use Disorders
Edythe D. London, Chelsea L. Robertson, and Terry J. Prins
47. Animal Models for the Study of Substance Use Disorders
Christopher J. Evans, J. David Jentsch, Brigitte L. Kieffer, Rafael J. Maldonado, and Catherine M. Cahill
48. Cellular and Molecular Mechanisms of Substance Use Disorders: Animal and Human Studies
Kathryn J. Reissner
49. Brain Development and the Risk for Substance Use Disorders
Sonia G. Ruiz, B.J. Casey, and Arielle Baskin-Sommers
50. Current Treatments for Substance Use Disorders
Adam D'Sa, Andrew L. Gaddis, and Eric C. Strain
51. Novel Approaches for Treating Substance Use Disorders
Matthew L. Banks
SECTION 7: DEMENTIA
Section Editor: Alison M. Goate
52. Diagnosis and Epidemiology of Dementia
William C. Kreisl and Christiane Reitz
53. Genetics of Alzheimer's Disease, Parkinson's Disease, and Lewy Body Dementia
Alan E. Renton, Brian Fulton-Howard, Shea J. Andrews, Edoardo Marcora, and Alison M. Goate
54. Neuroimaging and Fluid Biomarkers of Alzheimer's Disease
Brian A. Gordon and Suzanne Schindler
55. Molecular and Cellular Mechanisms of Alzheimer's Disease: Animal and Human Studies
Gareth R. Howell and Gregory W. Carter
56. Molecular and Cellular Mechanisms of Primary Tauopathies: Animal and Human Studies
Shiaoching Gong and Li Gan
57. Neurobiology of Lewy Body Dementias: Animal and Human Studies
James E. Galvin and Jose Tomas Bras
58. Current Treatments for Alzheimer's Disease and Other Dementias
Mary Sano and Judith Neugroschil
59. Novel Approaches for Treating Alzheimer's Disease and Other Dementias
M. Catarina Silva, David C. Butler, Sally Temple, and Steve J. Haggarty
SECTION 8: PEDIATRIC PSYCHIATRIC DISORDERS
Section Editor: Joseph D. Buxbaum
60. Diagnosis and Epidemiology of Pediatric Psychiatric Disorders
Magdalena Janecka, Artemis Briasouli, Vahe Khachadourian, and Abraham Reichenberg
61. Genetics of Pediatric-Onset Psychiatric Disorders
Tess Levy and Joseph D. Buxbaum
62. Neuroimaging in Pediatric Psychiatric Disorders
Timothy P.L. Roberts and Luke Bloy
63. Neurobiology of Autism Spectrum Disorders and Intellectual Disability: Animal and Human Studies
Alexandra Massa, Jesse Costales, Silvia De Rubeis, Jennifer Foss-Feig, Patrick R, Hof, and Alexander Kolevzon
64. Neurobiology of Attention Deficit Hyperactivity Disorder: Animal and Human Studies
Tess Levy and Joseph D. Buxbaum
65. Neurobiology of Tic Disorders and Obsessive-Compulsive Disorder: Animal and Human Studies
Christopher Pittenger
66. Neurobiology of Eating Disorders: Animal and Human Studies
Thomas Hildebrandt and Annabel Susanin
67. Current Treatments for Pediatric Psychiatric Disorders
Paige M. Siper, M. Pilar Trelles, Yael Kufert, and Dorothy E. Grice
68. Novel Approaches for Treating Pediatric Psychiatric Disorders
Niki P. Sabetfakhri and Edwin H. Cook, Jr.
SECTION 9: FUTURE DIRECTIONS OF PSYCHIATRY
Section Editor: Dennis S. Charney
69. The Present and Future of Psychiatric Diagnoses
Steven E. Hyman
70. The NIMH Research Domain Criteria Project: Toward Precision Medicine in Psychiatry
Bruce N. Cuthbert
71. Computational Psychiatry and the Bayesian Brain
Karl J. Friston and Xiaosi Gu
72. Digital Assessments of Psychiatric Disorders
Rachel E. Quist, Sukanya Bhattacharya, Sarah M. Chacko, and Nicholas C. Jacobson
73. Digital Therapies of Psychiatric Disorders: Focus on Depression Symptoms
Bruno Biagianti, Mor Nahum, Neta Yitzhak, and Sofia Vinogradov
74. Psychedelic Drugs as Treatment Agents
Rachel Yehuda, Lauren A. Lepow, Philip A. Bonnano, Tamar Glatman Zaretsky, Josimar Hernandez Antonio, and Kathleen M. Jagodnik
75. Psychiatry's Past Challenges and Future Opportunities
Ryan E. Lawrence and Jeffrey A. Lieberman
