Full Description
The involuntary movement disorder known as chorea can be due to a wide variety of neurological conditions, both genetic and acquired. This volume provides a comprehensive account of these conditions. While Huntington's disease is the prototypic inherited chorea, with the development of the genetic test for this disorder it has become apparent that a small but significant proportion of patients with this phenotype do not have this diagnosis. Although less common than Huntington's disease, it is vital to correctly diagnose these patients. Advances in molecular medicine have resulted in the identification of new genetic causes of chorea and expanded the phenotype of disorders not typically thought to cause this movement disorder. Non-genetic etiologies are discussed, including medications, structural lesions, psychogenic causes, and metabolic abnormalities.
This book describes in detail the latest clinical and etiological information regarding the causes of chorea. Psychopathology, management, and pathophysiology of chorea, are also addressed.
Many chapters are contributed by authors working at the forefront of research in the specific disorders, and provide the latest basic and clinical research, some from their own laboratories.
Contents
TABLE OF CONTENTS
Contributors
Chapter 1: Introduction: An Approach to the Patient with Chorea
Ruth H. Walker
Chapter 2: Functional Anatomy of Chorea
Jonathan W. Mink
Chapter 3: Huntington Disease
Rebecca M. Gilbert and Steven Frucht
Chapter 4: Benign Hereditary Chorea
Octavian R. Adam and Joseph Jankovic
Chapter 5: Huntington's Disease-like 2
Dobrila D. Rudnicki and Russell L. Margolis
Chapter 6: Chorea-acanthocytosis
Benedikt Bader, Adrian Danek, and Ruth H. Walker
Chapter 7: McLeod Syndrome
Hans H. Jung
Chapter 8: Neurodegeneration with Brain Iron Accumulation
Penelope Hogarth and Susan Hayflick
Chapter 9: Neuroferritinopathy
Alisdair McNeill and Patrick F. Chinnery
Chapter 10: Aceruloplasminemia
Frank Skidmore
Chapter 11: Chorea in prion diseases
Nayana Lahiri, Simon Mead, and Sarah J. Tabrizi
Chapter 12: Chorea in inherited ataxias
Guilherme G. Riccioppo Rodrigues and Jennifer G. Goldman
Chapter 13: Inherited Metabolic Diseases Causing Chorea in Childhood
Donald Gilbert
Chapter 14: Medication-induced Chorea
Marta San Luciano and Rachel Saunders-Pullman
Chapter 15: Metabolic Causes of Chorea
S. Elizabeth Zauber and Katie Kompoliti
Chapter 16: Structural Causes of Chorea
Nora L. Chan and Winona Tse
Chapter 17: Sydenham Chorea
Esther Cubo
Chapter 18: Paraneoplastic and other Autoimmune Choreas
Michael H. Pourfar
Chapter 19: Paroxysmal Chorea
Camilla Kilbane
Chapter 20: Psychiatric Aspects of the Neurodegenerative Choreas
Mark Walterfang, Andrew Evans, and Dennis Velakoulis
Chapter 21: Psychogenic Chorea
John C. Morgan, Shyamal H. Mehta, and Kapil D. Sethi
Chapter 22: Treatment of Chorea
Brandon Barton and Kathleen M. Shannon
Index
