基本説明
Sections: 1) concepts and methods, 2) genes and pathophysiologic mechanisms, 3) infectious agents and diseases.
Full Description
Infectious diseases are commonly regarded as a distinct category, with different causes and patterns than chronic or genetic disease. But in fact there are many varieties of genetic susceptibility to infection, the subject of this book, which will be divided into three sections: 1) concepts and methods, 2) genes and pathophysiologic mechanisms, and 3) infectious agents and diseases. No currently published text on either genetics or infectious diseases focuses on the genetic aspects of the special relationship between host and pathogen in the way envisioned for Section 1. No other work on the selected genes regulating immunity deals as systematically with the sequence variation/function relationships most pertinent to infection as planned for Section 2. And no other book gives as meaningful a picture of how these genes operate in infectious disease as Section 3 will.
Contents
SECTION I: METHODS AND TOOLS ; 1. Genetic Epidemiology of Infectious Disease ; 2. Laboratory Analysis of Genetic Variation ; 3. Mouse Models for Geentic Susceptibility to Infection in Humans ; SECTION II: IMMUNE RESPONSE GENES AND INFECTION ; 4. MHC Class I and Related Genes ; 5. MHC Class II and Related Genes ; 6. MHC Class I Polypeptide-Related Sequence A and B (MICA and MICB) Genes ; 7. Killer Immunoglobulin-Like Receptor and Related Genes ; 8. Red Blood Cell Genes ; 9. Immunoglobulin (Fc) Receptor and Related Genes ; 10. Mannose-Binding Lectin Genes ; 11. Complement Genes ; 12. Toll-Like Receptor Genes ; 13. Metal Transport Genes ; 14. Tumor Necrosis Factor and Related Genes ; 15. Cytokine Genes I (IL10, IL6, IL4, and the IL1 Family) ; 16. Cytokine Genes II (IFNG, IL12 and Their Receptor Genes) ; 17. Chemokine Receptor and Ligand Genes ; SECTION III: GENETIC DETERMINANTS OF INFECTIOUS DISEASES AND RESPONSE TO VACCINES ; 18. Immune Deficiency Disorders ; 19. Human Immunodeficiency Virus, Type 1 (HIV-1) and Acquired Immunodeficiency Syndrome ; 20. Human T Lymphotropic Virus, Type 1 (HTLV-1)-Associated Diseases ; 21. Hepatitis B and Hepatitis C Infection ; 22. Tuberculosis, Leprosy and Other Mycobacterial Diseases ; 23. Diseases Due to Encapsulated Bacteria ; 24. Malaria ; 25. Leishmaniasis ; 26. Schistosomiasis ; 27. Genetics and Immune Response to Vaccines
