Full Description
Vascular dementia, caused by multiple small strokes, is the second commonest cause of dementia behind Alzheimer's disease. In recent years there has been a radical reappraisal of the concept of vascular dementia and a move away from an Alzheimer-based diagnostic paradigm towards one more appropriately tailored for vascular disease. Vascular Cognitive Impairment presents a new definition for this class of cerebrovascular process with an emphasis on early detection, prompt treatment and the prevention of disease progression.
Vascular Cognitive Impairment: Preventable Dementia presents an overview of the current state of our knowledge in this field. It reviews the historical background, prevalence, risk factors and economic consequences of the condition. In addition, the book summarises our knowledge of the pathological process, describing insight derived from genetic and imaging studies, before examining opportunities for early diagnosis, prevention and the options for management, both now, and as a result of ongoing clinical trials.
With contributions from an expert team of international contributors, this book provides a comprehensive summary of the state-of-the-art in this field, providing a framework for a new understanding of a complex, disabling but Preventable condition.
Contents
1. Current criteria for vascular dementia: a critical appraisal ; 2. Historical evolution of the concept of vascular dementia ; 3. Prevalence and incidence patterns of vascular dementia ; 4. Evidence-based prognosis of vascular dementia: survival and rate of cognitive decline ; 5. The cost of vascular cognitive impairment ; 6. Histopathology ; 7. Experimental models of vascular dementia: a focus on white matter disease and incomplete infarction ; 8. Genetics of vascular dementia ; 9. Behavioural and psychological symptoms in vascular cognitive impairment ; 10. Cognitive patterns ; 11. Measurement of cognition ; 12. Neuropsychological differentiation of Alzheimer's disease and vascular dementia ; 13. Anatomical imaging ; 14. Cerebral blood flow and metabolism in vascular dementia ; 15. Neurochemical markers ; 16. Subtypes of vascular dementia and their pathogenesis: a critical overview ; 17. White matter changes in vascular dementia ; 18. Post-stroke dementia ; 19. Vasculitis, collagen vascular disease and vascular dementia ; 20. Vascular disorders and Alzheimer's disease ; 21. Treatment of vascular dementias ; 22. Clinical trials in vascular dementia ; 23. Prevention ; 24. Vascular cognitive impairment - a new concept
