For biology courses in engineering and computer science departments. Taking a system approach to expose modern biology, this book presents the fundamental system principles and parameters common to all living species. The straightforward examination begins with a presentation of molecular cell biology and progresses to the complex interrelationship between genes and proteins as observed in metabolic process, signal transduction, cell division and embryonic development. The text's unique approach provides a depiction of the human genome project, a review of high throughput biology and bioinformatic tools and a presentation of gene circuitry and pathway analysis as applied to cell division, development of embryo and metabolic pathways and expose of emerging proteomic science.
(NOTE: Each chapter begins with an Introduction and concludes with Assignments and References.) 1. The Chemistry of Life. Atoms. Molecules and Covalent Bonds. Ionic Compounds and Electrostatic Bonds. Water and Hydrogen Bonds. Lipids and Van der Waals Attratction. Acids and Bases. Chemical Reactions. Enzymes. More on Bioelements. 2. Macromolecules of Life. Fundamentals. Carbohydrates. Lipids. DNA & RNA. Proteins. Genetic Code. Protein Structure and Function. 3. Cells and Their Housekeeping Functions. Prokaryotes and Eukaryotes. Nuceleus. Organelles for Protein Synthesis and Transport. Cytoskeleton. Metabolic Processes and Mitochondria. Molecular Motors. Cell Membrane. Active Membrane Transport. 4. Gene Circuits. Gene to Protein. Gene Anatomy. Gene Circuits. Bionetworks. 5. Genomics. History of the Genome. Sequence Similarity and Homologous Genes. Decoding the Human Genome. Cutting and Sizing DNA. Making Multiple Copies. Sequencing. Gene Annotation. Plants and Animals with Modified Genomes. 6. Cell Adhesion and Communication. Modes of Cell Communication. Extracellular Matrix and Integrins. Cell-cell Adhesions and Cadherine. Examples from Signal Transduction Pathways. Crosstalk between Signal Transduction Pathways. 7. Cell Division and its Regulation. Modes of Cell Division. Molecular Basis of Cell Division. Cell Cycle Check Points. Phases of the Cell Cycle. Cell Culture. 8. Development of Multicellular Organisms. From Unfertilized Egg to Zygote. Cleavage: First Stage of Development. Gastrulation. Pattern-Generating Genes. Stem Cells and Tissue Engineering. 9. Large Scale Biology. Microarrays. Proteomics. Protein Structure. System Biology. Glossary.