Full Description
Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry.
This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth.
Contents
Part 1: General Aspects of Epigenetics in Psychiatry
1. Introduction to Epigenetics in Psychiatry
2. Outline of Epigenetics
3. A Brief History of Epigenetics in Psychiatry
4. Roles of Epigenetics in the Neural Stem Cell and Neuron
5. Role of Epigenetics in the Brain
6. Epigenetic Epidemiology of Psychiatric Disorders
7. ATAC-seq and Psychiatric Disorders
8. Single Cell RNA Sequencing and Psychiatric Disorders
9. Single Cell Analysis and Psychiatric Disorders
10. Laboratory Techniques in Psychiatric Epigenetics
11. Laboratory Epigenetic Models of Schizophrenia
12. Animal Models of Environmental Manipulations Resulting in Epigenetic Modifications That Increase Risk for Affective Disorders
Part 2: Epigenetics of Psychiatric Disorders
13. 5-Methycytosine and 5-Hydroxymethylcytosine in Schizophrenia
14. Pathogenic Histone Modifications in Schizophrenia are Targets for Therapy
15. Non-Coding RNAs and Psychiatric Disorders
16. Epigenetics of Bipolar Disorder
17. Epigenetics in Major Depressive Disorder
18. The Epigenetics of Suicide: The Critical Impact of Environment on Epigenetic Regulation in Suicide
19. Epigenetics in Posttraumatic Stress Disorder
20. Epigenetics and Cognitive Disorders
21. Epigenetics in Intellectual Disability
22. Epigenetics and Pervasive Developmental Disorders
23. Epigenetics in Child Psychiatry
24. Epigenetic Mechanisms of Drug Addiction Vulnerability
25. Epigenetics and Addiction to Alcohol
Part 3: Epigenetics in the Therapy of Psychiatric Disorders
26. Epigenetic Effects of Currently Used Psychotropic Drugs
27. DNA Methyltransferase Inhibitors and Psychiatric Disorders
28. Histone Deacetylase Inhibitors and Psychiatric Disorders
29. Psychotherapy and Epigenetics in Psychiatry
30. Gene-Specific Editing for Manipulating Specific Psychiatric Disorders
Part 4: Other Topics in Epigenetics in Psychiatry
31. Nutritional Effects on Epigenetics in Psychiatry
32. Systems Biology and the Epigenetics of Psychiatric disorders
33. Transgenerational (Heritable) Epigenetics and Psychiatric Disorders
34. Epigenetic Aspects of the Microbiome and Psychiatric Disorders
