Full Description
pH Interfering Agents as Chemosensitizers In Cancer Therapy, Volume Thirteen, provides a detailed overview of the chemosensitizers for the treatment of cancer spanning from biochemical and structural features to pharmacology and drug-design, including technological applications. The book is structured with innovative outlines and a distinction between experimental and clinical results. The continuous discovery and assessment of the role played by old/new synthetic drugs, natural compounds and technological applications has led to the urgent need of classification in terms of biological activity, mechanism of action, clinical outcomes, cancer cell lines sensible to the treatment, and potentialities to better orient research in this field.
Moreover, all the aspects relevant for medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, and molecular modeling studies) are strictly considered.
Contents
PART I General overview of the topic: An update1. General introduction about general mechanisms of resistance in cancer (hypoxia, efflux pumps, tumoral microenvironment) and use of chemosensitizers in association with drugs already in the market2. Clinical studies analysis3. Combination therapy4. Oncoimmunology
PART II Chemosensitizing agents with a validated mechanism of action5. pH regulators of the tumoral microenvironment6. Proton Pump Inhibitors (PPIs) and other pH buffering agents7. Selective hCA IX and XII inhibitors8. Epigenetic modulators9. Photosensitizing agents10. Efflux pumps and ABC transporter subfamily inhibitors (e.g., cyclosporin A, verapamil)11. Metalloproteinase inhibitors (e.g., ADAM17)12. Kinesin inhibitors13. Drug repurposing14. Innovative and putative targets for chemosensitizers15. Patent survey on chemosensitizers
PART III Chemosensitizing agents from natural sources16. Natural compounds as chemosensitizers: a lesson from plants17. Natural compounds: from food to clinic
PART IV Chemosensitizing agents: Computational tools and technological approaches18. Virtual screening and chemoinformatics of new library of chemosensitizers19. Nanostructures overcoming cancer resistance
