Full Description
The Human Hypothalamus: Neuroendocrine Disorders, Volume 181 in the Handbook of Clinical Neurology series, provides comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. This volume summarizes the role of the hypothalamus in neuroendocrine disorders, identifying the mechanism of action, disorder etiology, and best practices for assessment and treatment. Disorders covered include pituitary hypothalamic disorders of development and growth, hypothalamic tumor related disorders, hypothalamic autoimmune disorders and infection, disorders of vasopressin, water and sodium homeostasis, eating disorders, and gonadotropic hormone regulation disorders.
Contents
1. Introduction: The human hypothalamus and neuroendocrine disorders
SECTION 15 Structural disorders of the hypothalamo-pituitary region
2. Pituitary stalk interruption syndrome
3. Empty sella syndrome: Multiple endocrine disorders
4. Pituitary dysfunction after aneurysmal subarachnoidal hemorrhage
5. Septo-optic dysplasia
SECTION 16 Tumors of the hypothalamus
6. Hypothalamic hormone-producing tumors
7. Craniopharyngiomas primarily affecting the hypothalamus
SECTION 17 Neuroimmunological disorders
8. The stress-axis in multiple sclerosis: Clinical, cellular, and molecular aspects
9. Neuroendocrine manifestations of Langerhans cell histiocytosis
10. Neuroendocrine manifestations of Erdheim-Chester disease
11. Hypothalamitis and pituitary atrophy
12. Narcolepsy Type I as an autoimmune disorder
13. Neuromyelitis optica, aquaporin-4 antibodies, and neuroendocrine disorders
14. Antibodies against the pituitary and hypothalamus in boxers
15. Autoimmune diabetes insipidus
SECTION 18 Drinking disorders
16. Neuroimaging of central diabetes insipidus
17. Differential diagnosis of familial diabetes insipidus
18. The vasopressin-aquaporin-2 pathway syndromes
19. Adipsic diabetes insipidus
20. Animal models for diabetes insipidus
21. Nocturnal enuresis in children: The role of arginine-vasopressin
SECTION 19 Eating disorders
22. Monogenic human obesity syndromes
23. Hypothalamic microinflammation
24. Glucose and fat sensing in the human hypothalamus
25. Hypothalamus and neuroendocrine diseases: The use of human-induced pluripotent stem cells for disease modeling
26. Prader-Willi syndrome: Hormone therapies
27. Transcriptomics of the Prader-Willi syndrome hypothalamus
28. Disorders of hypothalamic function: Insights from Prader-Willi syndrome and the effects of craniopharyngioma
29. Animal models for Prader-Willi syndrome
30. Is there a hypothalamic basis for anorexia nervosa?
SECTION 20 Reproduction, olfaction and sexual behavior
31. Sexual differentiation of the human hypothalamus: Relationship to gender identity and sexual orientation
32. Klinefelter syndrome or testicular dysgenesis: Genetics, endocrinology, and neuropsychology
33. Neurobiology of puberty and its disorders
