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Full Description
Epigenetics and Reproductive Health, a new volume in the Translational Epigenetics series, provides a thorough overview and discussion of epigenetics in reproduction and implications for reproductive medicine. Twenty international researchers discuss epigenetic mechanisms operating during the formation of male and female gametes, fertilization and subsequent embryo and placental development, particularly in mammals and transgenerational epigenetic inheritance. This volume also addresses aberrant epigenetic changes influencing male and female infertility, pregnancy related disorders, and those potentially linked to therapeutic manipulations and assisted reproductive technologies. Emphasis is placed on identifying biomarkers for early detection of aberrant epigenetic mechanisms.
Later chapters examine the possibility of correcting these epigenetic dysfunctions, as well as current challenges and next steps in research, enabling new translational discoveries and efforts towards developing therapeutics.
Contents
SECTION I Spermatogenesis, oogenesis and fertility
1. Epigenome reprogramming in the male and female germ line
2. Genomic imprinting
3. Chromatin remodeling of the male genome during spermiogenesis and embryo development
4. Epigenetic regulation in stem cells
5. Aberrant epigenetics and reproductive disorders
SECTION II Pregnancy/developmental/placental epigenetics
6. Epigenetic reprogramming in the embryo
7. Epigenetic regulation during placentation
8. Epigenetic modulation during pregnancy and pregnancy related disorders
9. Epigenetic involvement in fetal and neonatal origins of late-onset disease
SECTION III Epigenetic - lifestyle, aging and environmental influence
10. Impact of environmental chemicals and endocrine disruptors on mammalian germ cell epigenome
11. Influence of nutrition on reproductive health through epigenetic mechanisms
12. Influence of stress and lifestyle on epigenetic modifications
13. Aging of male and female gametes
SECTION IV Reproductive cancer and epigenetics
14. Testicular and prostate cancers
15. Emerging patterns and implications of breast cancer epigenetics: An update of the current knowledge
16. Ovarian and endometrial cancers
17. Epigenetic aberrations in cervical cancer
SECTION V Epigenetics in diagnosis, prognosis and therapy
18. Natural molecules as epigenetic modifiers in reproduction
