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Full Description
The Neurobiology of Bipolar Disorder: Road to Novel Therapeutics combines the basic neurobiology of bipolar disorder with discussions of the most recent advances in research, including the interacting pathways implicated in the pathophysiology of bipolar disorder, genetic approaches and the pharmacogenomics of bipolar disorder. The basic foundational understanding of the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research combine to aid advanced students and researchers in their understanding of bipolar disorder management using novel and fast-acting pharmaceutical and neuromodulatory approaches.
Contents
1. Tackling the heterogeneity of bipolar disorder in the era of the Research Domain Criteria (RDoC)
2. The neurodevelopmental basis of Bipolar Disorder: Mechanisms and Implications
3. The neuroprogressive nature of Bipolar Disorder: Mechanisms and Implications
4. Immune mechanisms in Bipolar Disorder: evidence and implications
5. Mitochondrial pathways in Bipolar Disorder: mechanisms and implications
6. Neuro-oxidative and neuro-nitrosative mechanisms in bipolar disorder: evidence and implications
7. Mechanisms underpinning neurocognitive dysfunction in bipolar disorder
8. The evolution of animal models for bipolar disorder
9. Alteration in Circadian rhythms in bipolar disorder: mechanisms and implications
10. The genetics of bipolar disorder
11. Pharmacogenomics of bipolar disorder
12. Blood-brain barrier dysfunction as a pathophysiological mechanism of bipolar disorder
13. Induced Pluripotent stem cells as tools for the investigation of the neurobiology of bipolar disorder
14. Bipolar disorder as a gliopathy
15. Molecular Imaging findings in Bipolar disorder
16. Structural and functional neuroimaging findings in bipolar disorder
17. Epigenetic mechanisms of bipolar disorder
18. Bipolar disorder and cardiovascular dysfunction: mechanisms and implications
19. At-risk mental states for bipolar disorder
20. Stress, allostatic load and bipolar disorder: mechanisms and implications
21. Bipolar disorder, obesity and metabolic disturbances: mechanisms and implications
22. The gut-brain axis in bipolar disorder
23. The hypothalamic-pituitary-adrenal axis in bipolar disorder
24. Disturbed neuroplasticity pathways in bipolar disorder: mechanisms and implications
25. Aberrations in intracellular signaling pathways in bipolar disorder
26. The impact of early-life stress in the development and course of bipolar disorder: mechanisms and implications
27. Bipolar disorder and accelerated aging: mechanisms and implications
28. Suicidal behaviors in bipolar disorder
29. Pediatric bipolar disorder
30. Late-life bipolar disorder
31. Biomarkers for Bipolar Disorder
32. The mechanisms of action of lithium in bipolar disorder
33. Is there a biosignature for lithium response in bipolar disorder? Evidence and implications
34. Exercise as a treatment for bipolar disorder
35. Non-invasive neuromodulatory approaches for bipolar disorder
36. Novel therapeutic drug targets for bipolar disorder
37. The treatment of bipolar disorder in the era of precision psychiatry: challenges and opportunities
