Full Description
Nanotechnology for Oral Drug Delivery: From Concept to Applications discusses the current challenges of oral drug delivery, broadly revising the different physicochemical barriers faced by nanotechnolgy-based oral drug delivery systems, and highlighting the challenges of improving intestinal permeability and drug absorption. Oral delivery is the most widely used form of drug administration due to ease of ingestion, cost effectiveness, and versatility, by allowing for the accommodation of different types of drugs, having the highest patient compliance. In this book, a comprehensive overview of the most promising and up-to-date engineered and surface functionalized drug carrier systems, as well as opportunities for the development of novel and robust delivery platforms for oral drug administration are discussed. The relevance of controlling the physicochemical properties of the developed particle formulations, from size and shape to drug release profile are broadly reviewed. Advances in both in vitro and in vivo scenarios are discussed, focusing on the possibilities to study the biological-material interface. The industrial perspective on the production of nanotechnology-based oral drug delivery systems is also covered. Nanotechnology for Oral Drug Delivery: From Concept to Applications is essential reading for researchers, professors, advanced students and industry professionals working in the development, manufacturing and/or commercialization of nanotechnology-based systems for oral drug delivery, targeted drug delivery, controlled drug release, materials science and biomaterials, in vitro and in vivo testing of potential oral drug delivery technologies.
Contents
Part I: Biological aspects and properties of nanomaterials for oral drug delivery 1. Oral drug delivery: overview2. Organization of the intestinal mucosa and barriers to oral drug delivery3. Nanomaterials for oral drug administration4. Mucoadhesive and mucus-penetrating polymers for drug delivery5. Size, shape and surface charge considerations of orally delivered nanomedicines6. Modified drug release: current strategies and novel technologies for oral drug delivery7. Delivery platforms for oral drug administration8. (Trans)Buccal drug delivery
Part II: Advanced technologies for oral delivery applications9. Spray drying for the formulation of oral drug delivery systems10. Microdevices to successfully deliver orally administered drugs11. Batch and microfluidic reactors in the synthesis of enteric drug carriers12. 3D printing in oral drug delivery
Part III: Methods for the evaluation of oral drug delivery systems13. 3D intestinal models towards a more realistic permeability screening14. In vitro relevant information for the assessment of nanoparticles for oral drug administration15. In vivo testing of orally delivered nanoparticles
Part IV: Pharmaceutical industry perspective16. Industrial perspectives and future of oral drug delivery
