Full Description
Nervous System Drug Delivery: Principles and Practice helps users understand the nervous system physiology affecting drug delivery, the principles that underlie various drug delivery methods, and the appropriate application of drug delivery methods for drug- and disease-specific treatments. Researchers developing nervous system putative therapeutic agents will use this book to optimize drug delivery during preclinical assessment and to prepare for regulatory advancement of new agents. Clinicians will gain direct insights into pathophysiologic alterations that impact drug delivery and students and trainees will find this a critical resource for understanding and applying nervous system drug delivery techniques.
Contents
Section I. Physiology of Nervous System Drug Delivery
1. Fundamentals of Brain-Barrier Anatomy and Global Functions
2. Blood-Brain Barrier in Disease States
3. Pharmacokinetics of Systemic Drug Delivery
4. Pharmacokinetics of Drug Delivery Past the Blood-Brain Barrier
5. Anatomy and Physiology of Cerebrospinal fluid Dynamics
6. Pharmacokinetics of Polymeric Drug Delivery
7. Pharmacokinetic Models of Convection-Enhanced Drug Delivery
8. Mechanisms and Clinical Applications of Stem Cell Therapy
Section II. Nervous System Drug Delivery Techniques
9. Intravenous and Intravascular Drug Delivery
10. Blood-Brain Barrier Disruption
11. Ultrasonic Methods
12. Nanoparticles for Brain Tumor Delivery
13. Solute Transport in the Cerebrospinal Fluid: Physiology and Practical Implications
14. Drug-impregnated Polymer Delivery
15. Immunomodulatory Methods
16. Convection-Enhanced Drug Delivery in the Central Nervous System
17. Stem Cell Transplantation for Neurological Disease: Technical Considerations and Delivery Devices
18. CRISPR-Cas Gene Editing for Neurological Disease
Section III. Clinical Application of Nervous System Drug Delivery
19. Drug and Disease-Specific Paradigms for Drug Delivery to the Central Nervous System
20. Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Brain Tumors
21. Clinical Methods of Nervous System Drug Delivery for Tumors
22. Delivery Methods for Treatment of Genetic Disorders
23. Direct Convective of Nervous System Drug Delivery for Patients with Neurodegenerative Disorders
24. Central Nervous System Drug Delivery after Ischemic or Hemorrhagic Stroke
25. Intrathecal Drug Delivery for Cancer Pain
