Full Description
Modeling and Control of Infectious Diseases in the Host: With MATLAB and R provides a holistic understanding of health and disease by presenting topics on quantitative decision-making that influence the development of drugs. The book presents modeling advances in different viral infections, dissecting detailed contributions of key players, along with their respective interactions. By combining tailored in vivo experiments and mathematical modeling approaches, the book clarifies the relative contributions of different underlying mechanisms within hosts of the most lethal viral infections, including HIV, influenza and Ebola. Illustrative examples for parameter fitting, modeling and control applications are explained using MATLAB and R.
Contents
Part 1. Theoretical Biology Principles1. Introduction2. Mathematical Modeling Principles3. Model Parameter Estimation
Part 2. Modeling Host Infectious Diseases4. Modeling Influenza Virus Infection5. Modeling Ebola Virus Infection6. Modeling HIV Infection7. HIV Evolution During Treatment
Part 3. Advanced Topics in Control Theory8. Optimal Therapy Scheduling9. Suboptimal Therapy Scheduling10. PK/PD-based Impulsive Control
