代謝表現型ハンドブック The Handbook of Metabolic Phenotyping

Lindon, John C. (EDT)/ Nicholson, Jeremy K. (EDT)/ Holmes, Elaine (EDT)

Elsevier Science Publishing Co Inc（2018/10発売）

• 製本 Paperback:紙装版/ペーパーバック版／ページ数 619 p.
• 言語 ENG
• 商品コード 9780128122938
• DDC分類 543

Full Description

The Handbook of Metabolic Phenotyping is the definitive work on the rapidly developing subject of metabolic phenotyping. It explores in detail the wide array of analytical chemistry and statistical modeling techniques used in the field, coupled with surveys of the various application areas in human development, nutrition, disease, therapy, and epidemiology to create a comprehensive exploration of the area of study. It covers recent studies that integrate the various -omics data sets to derive a systems biology view. It also addresses current issues on standardization, assay and statistics validation, and data storage and sharing. Written by experts with many years of practice in the field who pioneered many of the approaches widely used today, The Handbook of Metabolic Phenotyping is a valuable resource for postgrads and research scientists studying and furthering the field of metabolomics.

Contents

1. An Overview of Metabolic Phenotyping and Its Role in Systems Biology

2. NMR Spectroscopy Methods in Metabolic Phenotyping

3. The Role of Ultra Performance Liquid Chromatography-Mass Spectrometry in Metabolic Phenotyping

4. GC-MS-Based Metabolic Phenotyping

5. Metabolic Phenotyping Using Capillary Electrophoresis Mass Spectrometry

6. Supercritical Fluid Chromatography for Metabolic Phenotyping: Potential and Applications

7. The iKnife: Development and Clinical Applications of Rapid Evaporative Ionization Mass Spectrometry

8. Univariate Statistical Modeling, Multiple Testing Correction, and Visualization in Metabolome-Wide Association Studies

9. Multivariate Statistical Methods for Metabolic Phenotyping

10. Data-Driven Visualizations in Metabolic Phenotyping

11. Big Data and Databases for Metabolic Phenotyping

12. Progress in Standardization of Metabolic Phenotyping Data

13. Conception, Implementation and Operation of Large-Scale Metabolic Phenotyping Centres: Phenome Centres

14. Applications of Metabolic Phenotyping in Pharmaceutical Research and Development

15. Metabolic Phenotyping in Nutrition Research

16. Metabolic Phenotyping in Clinical Practice

17. Applications of Metabolic Phenotyping in Epidemiology

18. Influence of the Human Gut Microbiome on the Metabolic Phenotype

19. Linking Metabolic Phenotyping and Genomic Information

20. Metabolic Phenotyping: History, Status, and Prospects