- ホーム
- > 洋書
- > 英文書
- > Science / Mathematics
Full Description
The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer's, Parkinson's, frontotemporal dementia, ALS, Huntington's, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common.
This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field.
Contents
1. General Overview
2. Prion Diseases
3. Alzheimer's disease: towards a quantitative biological approach in describing its natural history and underlying mechanisms
4. Neurodegeneration and the ordered assembly of Tau
5. ALS and Other TDP43 Proteinopathies
6. Parkinson's Disease and Other Synucleinopathies
7. Huntington's Disease and Other Polyglutamine Disorders
8. Prion-like propagation in Neurodegenerative Diseases
9. Neurodegenerative Diseases as Protein Folding Disorders
10. Heat shock proteins and protein quality control in Alzheimer's disease
11. Neurodegenerative Diseases and Autophagy
12. Neurodegenerative Diseases and Axonal Transport
13. Mitochondrial Function and Neurodegenerative Diseases
14. Neurodegenerative Diseases and Non-cell autonomous toxicity
15. Neurodegenerative Diseases and RNA-mediated toxicity
16. Neuroinflammation in Age-Related Neurodegenerative Diseases
17. Neurodegenerative Diseases and the Aging Brain
