Dyneins : Dynein Mechanics, Dysfunction, and Disease （2ND）

King, Stephen M. (EDT)

Academic Press Inc（2017/11発売）

• 製本 Hardcover:ハードカバー版／ページ数 530 p.
• 言語 ENG
• 商品コード 9780128094709

Full Description

Dyneins: Structure, Biology and Disease, Second Edition, offers a broad view of dyneins mechanics, dysfunction, and disease, providing an overview of dyneins from structure and function, to dysfunction and disease.

Since the first edition, enormous strides have been taken in understanding dynein structure, its organization in the axoneme, single molecule motor mechanics, and the consequences of defects for human biology, disease, and development.

To account for these enormous strides, the second edition is extensively revised. Additionally, the coverage has expanded from 24 to 42 chapters, and is now housed in two volumes. Much of the expanded coverage occurs in Volume 2 which focuses on dynein dysfunction and disease, such as the role of dynein and cancer.

Volume 1 covers the history and evolution of dyneins, dyneins in ciliary biology, and cytoplasmic dynein biology, while Volume 2 covers the structure and mechanics of dynein motors and dynein dysfunction and disease.

Contents

I. Structure and Mechanics of Dynein Motors
1. Electron microscopy of isolated dynein complexes and the power stroke mechanism
2. Mechanism and regulation of dynein motors
3. Structural analysis of dynein intermediate and light chains
4. Biochemical purification of axonemal and cytoplasmic dyneins
5. Single molecule dynein motor mechanics in vitro
6. Biophysical properties of dynein in vivo
7. Mechanics of bidirectional cargo transport
8. Chemical probes for dynein
9. Computational modeling of dynein activity and the generation of flagellar beating waveforms

II. Dynein Dysfunction and Disease
10. Impacts of virus-mediated manipulation of host dynein
11. Use of mouse genetics to probe cytoplasmic dynein function
12. Cytoplasmic dynein and its regulators in neocortical development and disease
13. Cytoplasmic dynein dysfunction and neurodegenerative disease
14. Dynein dysfunction as a cause of primary ciliary dyskinesia and other ciliopathies
15. Severe skeletal abnormalities caused by defects in retrograde intraflagellar transport dyneins
16. Ciliary dynein dysfunction as a consequence of chronic alcohol exposure
17. Dynein-based motility of pathogenic protozoa
18. Dynein axonemal light chain 4: involvement in congenital mirror movement disorder
19. Does dynein influence the non-Mendelian inheritance of chromosome 17 homologues in male mice?