Full Description
Noradrenergic Signaling and Astroglia integrates what is known about the active role of astroglia in the locus coeruleus-noradrenergic system and outlines the most recent advances in the field. It discusses the molecular mechanisms underlying norepinephrine-induced receptor activation in astroglia, cellular metabolism and CNS energy provision, in vitro, ex vivo, and in vivo models, gliosignalling and neuronal activity, and astroglial networks, gap junctions, and morphological plasticity. The book also addresses the role of astroglial adrenergic receptor activation in memory formation, cognition, regulation of sleep homeostasis, and lastly in neurological disorders, including trauma (cellular edema), neurodegeneration (Alzheimer's disease), and neuroinflammation (multiple sclerosis). Noradrenergic Signaling and Astroglia is a valuable source of new knowledge for a wide audience, including graduate students, post-doctoral fellows, and researchers in neuroscience, life sciences, and the biological and biomedical sciences.
Contents
1. Locus coeruleus noradrenergic neurons and astroglia in health and disease
2. Astroglial adrenergic receptor signaling in brain cortex
3. White matter astrocytes: Adrenergic mechanisms
4. Role for astroglial a1-adrenergic receptors in glia-neuron communications and aging-related metaplasticity in the neocortex
5. Adrenergic Ca2+ and cAMP excitability: Effects on glucose availability and cell morphology in astrocytes
6. Adrenergic receptors on astrocytes modulate gap junctions
7. Fluxes of lactate into, from, and among gap junction-coupled astroglia and their interaction with noradrenaline
8. Dialogue between astrocytes and noradrenergic neurones via L-lactate
9. Noradrenergic system and memory: The role of astrocytes
10. Hippocampal noradrenaline regulates spatial working memory in the rat
11. Enteric astroglia and noradrenergic/purinergic signaling
12. Noradrenaline drives structural changes in astrocytes and brain extracellular space
13. Signalling pathway of B-adrenergic receptor in astrocytes and its relevance to brain oedema
14. Noradrenaline, astroglia, and neuroinflammation
15. Astrocytic B2 adrenergic receptors and multiple sclerosis
16. Potentiation of B-amyloid-induced cortical inflammation by noradrenaline and noradrenergic depletion: Implications for Alzheimer's disease
