Full Description
Bio-Instructive Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine explores musculoskeletal tissue growth and development across populations, ranging from elite athletes to the elderly. The regeneration and reparation of musculoskeletal tissues present the unique challenges of requiring both the need to withstand distinct forces applied to the body and ability to support cell populations.
The book is separated into sections based on tissue type, including bone, cartilage, ligament and tendon, muscle, and musculoskeletal tissue interfaces. Within each tissue type, the chapters are subcategorized into strategies focused on cells, hydrogels, polymers, and other materials (i.e. ceramics and metals) utilized in musculoskeletal tissue engineering applications.
In each chapter, the relationships that exist amongst the strategy, stem cell differentiation and somatic cell specialization at the intracellular level are emphasized. Examples include intracellular signaling through growth factor delivery, geometry sensing of the surrounding network, and cell signaling that stems from altered population dynamics.
Contents
Part I: Introduction
Chapter 1: Bio-Instructive Cues in Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine
Chapter 2: Functionalizing With Bioactive Peptides to Generate Bio-Instructive Scaffolds
Part II: Bone
Chapter 3: Bio-Instructive Scaffolds for Bone Regeneration
Part III: Tendon/Ligament
Chapter 4: Bio-Instructive Scaffolds for Tendon/Ligament Regeneration
Part IV: Cartilage
Chapter 5: Bio-Instructive Scaffolds for Cartilage Regeneration
Part V: Muscle
Chapter 6: Ultrastructure and Biomechanics of Skeletal Muscle ECM: Implications in Tissue Regeneration
Chapter 7: Bio-Instructive Scaffolds for Muscle Regeneration: NonCrosslinked Polymers
Chapter 8: Bio-Instructive Scaffolds for Skeletal Muscle Regeneration: Conductive Materials
Part VI: Musculoskeletal Interfaces
Chapter 9: Bio-Instructive Scaffolds for Musculoskeletal Interfaces
