Full Description
Individualized Drug Therapy for Patients: Basic Foundations, Relevant Software and Clinical Applications focuses on quantitative approaches that maximize the precision with which dosage regimens of potentially toxic drugs can hit a desired therapeutic goal. This book highlights the best methods that enable individualized drug therapy and provides specific examples on how to incorporate these approaches using software that has been developed for this purpose.
The book discusses where individualized therapy is currently and offers insights to the future. Edited by Roger Jelliffe, MD and Michael Neely, MD, renowned authorities in individualized drug therapy, and with chapters written by international experts, this book provides clinical pharmacologists, pharmacists, and physicians with a valuable and practical resource that takes drug therapy away from a memorized ritual to a thoughtful quantitative process aimed at optimizing therapy for each individual patient.
Contents
Section I: Basic Techniques for Individualized Therapy
1. Basic Pharmacokinetics and Dynamics for Clinicians
2. Describing Drug Behavior in Groups of Patients
3. Developing Maximally Precise Dosage Regimens for Patients - Multiple Model (MM) Dosage Design
4. Optimizing Laboratory Assay Methods for Individualized Therapy
5. Evaluation of Renal Function
Section II: The Clinical Software
6. Using the BestDose Clinical Software - Examples With Aminoglycosides
7. Monitoring the Patient: Four Different Bayesian Methods to Make Individual Patient Drug Models
8. Monitoring Each Patient Optimally: When to Obtain the Best Samples for Therapeutic Drug Monitoring
9. Optimizing Individualized Drug Therapy in the ICU
10. Quantitative Modeling of Diffusion Into Endocardial Vegetations, the Postantibiotic Effect, and Bacterial Growth and Kill
11. Individualizing Digoxin Therapy
Section III: Clinical Applications of Individualized Therapy
12. Optimizing Single-Drug Antibacterial and Antifungal Therapy
13. Combination Chemotherapy With Anti-Infective Agents
14. Controlling Antiretroviral Therapy in Children and Adolescents with HIV Infection
15. Individualizing Tuberculosis Therapy
16. Individualizing Transplant Therapy
17. Individualizing Dosage Regimens of Antineoplastic Agents
18. Controlling Busulfan Therapy in Children
19. Individualizing Antiepileptic Therapy for Patients
20. Individualizing Drug Therapy in the Elderly
21. The Present and Future State of Individualized Therapy
