Full Description
Mesenchymal stromal/ stem cells (MSCs) represent a heterogeneous cell population with immunomodulating, tissue repairing, differentiating, migratory and angiogenic abilities, making them important tools for clinical and translational research. An understanding of the role of MSCs in modulating tumor growth provides a glimpse into their role in non-pathological tissue remodeling and potential regenerative tissue therapies.
Mesenchymal Stromal Cells as Tumor Stromal Modulators is a comprehensive source for the understanding of the role of MSCs as ubiquitous connective tissue cell components, which may have both direct and indirect effects on the tumor microenvironment and potential for regenerative therapeutics for various diseases. Using cancer as a model disease, this book explores the transformative role MSCs play in the recruitment of disease cells, cell repair and immunological defenses.
Contents
1. What are Mesenchymal Stromal Cells? Origin and Discovery of Mesenchymal Stromal Cells
Jorge Domenech
2. Mesenchymal Stem/Stromal Cells from Adult Tissues
Regina Coeli dos Santos Goldenberg, Debora Bastos Mello and Karina Dutra Asensi
3. Mesenchymal Stem/Stromal Cells from Neonatal Tissues
Alp Can, Zeynep Gulhan Yigman
4. Mesenchymal stem/Stromal Cells Derived from Pluripotent Stem Cells
Carlos Luzzani, Santiago G. Miriuka
5. Mesenchymal Stem/Stromal Cells as Biological Factories
Addeli Bez Batti Angulski, Alejandro Correa, Marco Augusto Stimamiglio
6. MSC recruitment from distant and local tissues in homeostasis and tissue remodeling
Lindolfo da Silva Meirelles, Nance Beyer Nardi
7. Mesenchymal stem/stromal cell trafficking and homing
Armel Herve Nwabo Kamdje, Paul Faustin Seke Etet, Paul Takam Kamga, Jean Marc Muller, Giulio Bassi, Erique Lukong, Raghuveera Kumar Goel, Mauro Krampera
8. Tumor-Secreted Factors That Induce Mesenchymal Stromal Cell Chemotaxis
Kevin Anton and John Glod
9. Mesenchymal stromal cells recruitment by gastrointestinal carcinomas
Guillermo D. Mazzolini
10. Mesenchymal Stem/Stromal Cell Recruitment by Central Nervous System Tumors
Brittany C. Parker Kerrigan and Frederick F. Lang
11. Mesenchymal stem cell transition to tumor-associated stromal cells contributes to cancer progression
Karen M. Bussard,Erika Spaeth, Lysette A. Mutkus, Kristina A. Stumpf and Frank C. Marini
12. Mesenchymal Stromal Cells and Tumor Angiogenesis
Shih-Chieh Hung
13. Role of MSCs in Anti-Tumor Drug Resistance
Augustin Le Naour and Bettina Couderc
14. Multifunctional Roles of Tumor-Associated Mesenchymal Stem Cells in Cancer Progression
Antoine E. Karnoub
15. Mesenchymal Stem Cells and Metastatic Niches
Leandro Marcelo Martinez, Vivian Labovsky, Valeria Beatriz Fernández Vallone, Choi Hosoon, Mariana Amorós, Casie Phillips and Norma Alejandra Chasseing
16. The bone marrow microenvironment as a regulator of tumor dormancy
Makiko Ono and Takahiro Ochiya
17. MSC and the tumor immune system
Nykia D. Walker, George R. Nahas, Jessian Munoz, Justin Lucas, Piotr Pobiarzyn and Pranela Rameshwar
18. The inflammatory environment and its effects on mesenchymal stem cells
Krisztian Nemeth
19. All Aboard: Mesenchymal Stem Cells as Cell Carriers for Virotherapy
Julius W. Kim, Jason Murphy, Alan L. Chang, DrewA. Spencer, J. Robert Kane,DeepakKanojia, Aida Rashidi, Jacob S. Young and Maciej S. Lesniak
20. Engineered Mesenchymal Stem/ Stromal Cells for Cellular Therapies
Sreevidhya Ramakrishnan, Debanjan Sarkar
21. Extracellular Vesicles from Mesenchymal Stem Cells and their potential in Tumor Therapy
Johann Mar Gudbergsson and Meg Duroux
22. MSCs therapy: defining the risks of MSC therapy. Ex vivo expanded MSCs for therapeutic purposes
Myriam N. Bouchlaka, Peiman Hematti and Christian M. Capitini
23. Concluding Remarks
Mariana Garcia and Marcela Bolontrade
