Biology and Engineering of Stem Cell Niches

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¥19,638

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Biology and Engineering of Stem Cell Niches

Vishwakarma, Ajaykumar (EDT)/ Karp, Jeffrey M (EDT)

ウェブストア価格 ¥30,412（本体¥27,648）
Academic Press Inc（2017/04発売）
外貨定価 US$ 150.00
ポイント 276pt

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製本 Paperback:紙装版/ペーパーバック版／ページ数 642 p.
言語 ENG
商品コード 9780128027349
DDC分類 616.02774

Full Description

Biology and Engineering of Stem Cell Niches covers a wide spectrum of research and current knowledge on embryonic and adult stem cell niches, focusing on the understanding of stem cell niche molecules and signaling mechanisms, including cell-cell/cell-matrix interactions.

The book comprehensively reviews factors regulating stem cell behavior and the corresponding approaches for understanding the subsequent effect of providing the proper matrix molecules, mechanical cues, and/or chemical cues. It encompasses a variety of tools and techniques for developing biomaterials-based methods to model synthetic stem cell niches in vivo, or to enhance and direct stem cell fate in vitro.

A final section of the book discusses stem cell niche bioengineering strategies and current advances in each tissue type.

Part I. Biology of Stem Cell Niches and Molecular Mechanisms
1. The Need to Study, Mimic, and Target Stem Cell Niches
2. Harnessing the Biology of Stem Cells' Niche
3. Pluripotent Stem Cell Microenvironment
4. Regulation of Hematopoietic Stem Cell Dynamics by Molecular Niche Signaling
5. HSC Niche: Regulation of Mobilization and Homing
6. Neuronal Stem Cell Niches of the Brain
7. Cardiovascular Stem Cell Niche
8. Intestinal Epithelial Lgr5+ Stem Cell Niche and Organoids
9. The Epithelial Stem Cell Niche in Skin
10. The Satellite Cell Niche in Skeletal Muscle
11. The Cancer Stem Cell Niche
12. Cellular Senescence and Stem Cell Niche

Part II. Biochemical and Physical Cues in The Stem Cell Niche Directing Cell Fate
13. Matrix Chemistry Controlling Stem Cell Behavior
14. Matrix Growth Factor and Surface Ligand Presentation
15. Effect of Matrix Mechanical Forces and Geometry on Stem Cell Behavior
16. Wettability Effect on Stem Cell Behavior
17. Fluid Flow Control of Stem Cells With Investigation of Mechanotransduction Pathways
18. Hypoxia Regulation of Stem Cell: Mechanisms, Biological Properties, and Applications

Part III. Designing Smart Biomaterials to Mimic and Control Stem Cell Niche
19. Polymer Design and Development
20. Design and Development of Ceramics and Glasses
21. Surface Functionalization of Biomaterials
22. Biofunctional Hydrogels for Three-Dimensional Stem Cell Culture
23. Technologies to Engineer Cell Substrate Mechanics in Hydrogels
24. Micro- and Nanosurface Patterning Technologies
25. Self-Assembled Nanostructures (SANs)
26. Biomimetic Nanofibers as Artificial Stem Cell Niche

Part IV. Bioengineering Strategies to Model Synthetic Stem Cell Niches
27. Employing Microfluidic Devices to Induce Concentration Gradients
28. Engineering Niches for Embryonic and Induced Pluripotent Stem Cells
29. Engineering Niches for Cardiovascular Tissue Regeneration
30. Engineering Niches for Blood Vessel Regeneration
31. Engineering Niches for Bone Tissue Regeneration
32. Engineering Vascular Niche for Bone Tissue Regeneration
33. Engineering Niches for Cartilage Tissue Regeneration
34. Engineering Niches for Stem and Progenitor Cell Differentiation Into Immune Cells
35. Engineering Niches for Skin and Wound Healing
36. Designing Stem Cell Niche for Liver Development and Regeneration
37. Engineering the Niche for Intestinal Regeneration