Full Description
Personalized Immunosuppression in Transplantation: Role of Biomarker Monitoring and Therapeutic Drug Monitoring provides coverage of the various approaches to monitoring immunosuppressants in transplant patients, including the most recently developed biomarker monitoring methods, pharmacogenomics approaches, and traditional therapeutic drug monitoring.
The book is written for pathologists, toxicologists, and transplant surgeons who are involved in the management of transplant patients, offering them in-depth coverage of the management of immunosuppressant therapy in transplant patients with the goal of maximum benefit from drug therapy and minimal risk of drug toxicity.
This book also provides practical guidelines for managing immunosuppressant therapy, including the therapeutic ranges of various immunosuppressants, the pitfalls of methodologies used for determination of these immunosuppressants in whole blood or plasma, appropriate pharmacogenomics testing for organ transplant recipients, and when biomarker monitoring could be helpful.
Contents
Chapter 1. Overview of the pharmacology and toxicology of immunosuppressant agents that require therapeutic drug monitoring
Chapter 2. Limitations of Immunoassays Used for Therapeutic Drug Monitoring of Immunosuppressants
Chapter 3. Application of liquid chromatography combined with mass spectrometry or tandem mass spectrometry for therapeutic drug monitoring of immunosuppressants
Chapter 4. Monitoring Free Mycophenolic Acid Concentration: Is There any Clinical Advantage?
Chapter 5. Pharmacogenomics aspect of immunosuppressant therapy
Chapter 6. Biomarker monitoring in immunosuppressant therapy: An overview
Chapter 7. Graft-derived cell-free DNA as a Marker of Graft Integrity after Transplantation
Chapter 8. Biomarkers of tolerance in kidney transplantation
Chapter 9. Intracellular concentrations of immunosuppressants
Chapter 10. Markers of lymphocyte activation and proliferation
Chapter 11. Monitoring Calcineurin inhibitors response based on NFAT-regulated gene expression
