Full Description
Molecular Aspects of Alcohol and Nutrition is a valuable resource for nutrition researchers and nutritionists who study or treat alcohol-related diseases. Experts from across the field of alcohol research explain how alcohol disrupts normal fat, carbohydrate, and protein metabolic processes occurring in the liver as well as other parts of the body.
The book discusses how this can lead to alcoholic liver disease (ALD) as well as contribute to the onset of Type 2 diabetes and the metabolic syndrome. It also explores how alcohol affects nutrient absorption in the gastrointestinal tract and can lead to anemia and reduced amounts of fat soluble vitamins.
This book explores both the primary and secondary consequences of alcohol consumption. Chapters in the first section investigate the basic science of alcohol metabolism - focusing on how alcohol and its toxic metabolites disrupt and impair normal nutrient regulation at the molecular level. Further chapters explore how alcohol affects many extra-hepatic organs and tissues as well as the secondary consequences of alcohol consumption such as reduced levels of minerals like magnesium, calcium, and trace elements like zinc.
Contents
Section 1. General and Introductory Aspects
1. Nutrients and Liver Energy Metabolism
Daniel Gyamfi and Kwabena Owusu Danquah
2. Alcohol Metabolism: general aspects
Reem Ghazali and Vinood B. Patel
Section 2. Molecular biology of the cell
3. Alcohol and aldehyde dehydrogenases: molecular aspects
Kwabena Owusu Danquah
4. Apoptosis and alcohol
F.A. Middleton
5. Pathogenic Mechanisms in Alcoholic Liver Disease (ALD): emerging role of Osteopontin
Wing-Kin Syn and Jason D. Coombes
6. The Role of CD36 in the Pathogenesis of Alcohol-Related Disease
Caleb T. Epps, Robin D. Clugston, Amit Saha, William S. Blaner and Li-Shin Huang
7. Thiamine deficiency in alcoholics
Ann M. Manzardo
8. Vitamin B regulation of Alcoholic Liver Disease
Charles H. Halsted and Valentina Medici
9. Vitamin D and alcohol interactions and implication for bone
Emilio Gonzalez-Reimers, Geraldine Quintero-Platt, Antonio Martinez-Riera and Francisco Santolaria-Fernandez
10. Antioxidant treatment of alcoholism
Camila Siqueira Silva, Helio Vannucchi and Guilherme Vannucchi Portari
11. Selenium dietary supplementation and oxidative balance in alcoholism
Olimpia Carreras, María Luisa Ojeda and Fatima Nogales
12. Role of zinc in alcoholic liver disease
Zhanxiang Zhou
13. Interactions between alcohol and folate
Bogdan Cylwik
14. Effects of Acetladehyde on intestinal barrier function
D. Jonkers and Elhaseen Elamin
15. Cholesterol regulation by leptin in alcoholic liver disease
Balasubramaniyan Vairappan
16. CRF system and alcohol consumption
Andrey E. Ryabinin and William J. Giardino
17. Metabolic profiling approaches for biomarkers of ethanol intake
Helen G. Gika and Ian D. Wilson
Section 3. Genetic machinery and its function
18. Gene expression in alcoholism: an overview
Reem Ghazali and Vinood B. Patel
19. Cytochrome P4502E1 Gene Polymorphisms in alcoholics
Tao Zeng and K.-Q. Xie
20. Genes associated with alcohol withdrawal
Kesheng Wang and Liang Wang
21. Alcohol and epigenetic modulations
Claudio D'Addario and Mauro Maccarrone
22. miRNA Expression in the alcoholic liver disease
Shashi Bala
22. Alcohol and DNA Methylation
Feng C. Zhou
24. Ethanol-mediated carcinogenesis molecular insights as an overview
Helmut K. Seitz
25. Molecular link between alcohol and breast cancer: the role of salsolinol
Mariko Murata, Kaoru Midorikawa and Shosuke Kawanishi
26. Ethanol impairs Phospholipase D signaling in astrocytes
Ute Burkhardt and Jochen Klein
27. Metabolite changes in alcohol gonadotoxicity
Ganna M. Shayakhmetova and Larysa B. Bondarenko
28. Hepcidin and iron dysregulation in alcoholics
Kosha Mehta and Vinood B. Patel
