Full Description
Neuropsychiatric Disorders and Epigenetics is a comprehensive reference for the epigenetic basis of most common neuropsychiatric disorders. The volume is organized into chapters representing individual neuropsychiatric disorders, from addition to obesity contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of epigenetic mechanisms including DNA modification, histone post-translational modification, chromatin organization and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states is particularly relevant o disease.
Recent discoveries in epigenetic research enabled by epic advances in genomic technologies have positioned the field for broad translation to therapeutic interventions for previously unmanageable disorders Neuropsychiatric disorders represent a prime target of epigenetic interventions as they are highly debilitating, often chronic diseases with enormous costs to society. Thus, this volume will help define epigenetics as a key player in neuropsychiatric disorders, highlighting the full spectrum of epigenetic mechanisms underlying such disorders and introducing the vast range of epigenetic therapies under development.
Contents
Preface
Dag H. Yasui, Jacob Peedicayil and Dennis R. Grayson
Section I. Neuropsychiatric Disorders and Epigenetics: General Aspects
1. Introduction to Neuropsychiatric Disorders and Epigenetics
Dag H. Yasui, Jacob Peedicayil and Dennis R. Grayson
2. Environmental Factors and Epigenetics of Neuropsychiatric Disorders
Anke Hoffmann and Dietmar Spengler
3. Epigenetic Biomarkers in Neuropsychiatric Disorders
Chin-Chuen Lin, Tiao-Lai Huang
Section II: Epigenetics of Neuropsychiatric Disorders
4. Epigenetics and Cognitive Disorders -Translational Aspects
Fabio Coppedè
5. Epigenetics in Pervasive Developmental Disorders - Translational Aspects
Takeo Kubota
6. Epigenetic causes of intellectual disability - the fragile X syndrome paradigm
Elisabetta Tabolacci, Giovanni Neri
7. Epigenetics of Attention-Deficit Hyperactivity Disorder
Nader Perroud, Sébastien Weibel, Jean-Michel Aubry, Alexandre Dayer
8. The epigenetics of brain aging and psychiatric disorders
Huan Gong, Xiangru Xu
9. Epigenetic therapy may alleviate cognitive deficits in Down syndrome by downregulating overexpressed chromosome 21 gene products
Alain D. Dekker, Peter P. De Deyn and Marianne G. Rots
10. Epigenetics and Multiple Sclerosis
Lara Kular, Gonçalo Castelo-Branco and Maja Jagodic
11. Epigenetics and Migraine
Siew Hua Gan and Munvar Miya Shaik
12. The role of epigenetics in the pathophysiology of epilepsy
Sung Min Nam and Kyung-Ok Cho
13. Epigenetic Dysregulation in Brain Tumors and Neurodevelopment
Marco M. Hefti and Nadejda Tsankova
14. Epigenetics and Cerebrovascular Diseases
Carolina Soriano-Tárraga, Jordi Jiménez-Conde and Jaume Roquer
15. Epigenetics and Eating Disorders
Helge Frieling, Vanessa Buchholz
16. Epigenetics in Obesity
Brian M. Shewchuk
17. Epigenetics and Drug Addiction-Translational Aspects
Jian Feng
18. Epigenetics and Alcohol Use Disorders
Sneha Sagarkar and Amul Sakharkar
Section III: Summary and Outlook
19. Summary and Outlook
Dag H. Yasui, Jacob Peedicayil and Dennis R. Grayson
