Full Description
Biological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines.
Though discussed in specific subsections of existing books, dsDNA and its immunogenic properties has never received the complete treatment given in this book. Biological DNA Sensor approaches the impact of dsDNA's immunogenicity on disease and vaccinology holistically. It paints a complete and concise picture on the topic so you can understand this area of study and make more informed choices for your respective research needs. Chapters are authored by researchers who are renowned for their research focus, ensuring that this book provides the most complete views on the topics.
Contents
1. Route to discovering the immunogenic properties of DNA from TLR9 to cytosolic DNA sensors
Choon Kit Tang, Cevayir Coban, Shizuo Akira, Ken J Ishii
2. The PYHIN family of molecules and their functions sensing dsDNA
Sivapriya Kailasan Vanaja, Vijay A. K. Rathinam, Katherine A. Fitzgerald
3. The central role of STING-TBK1 in the DNA sensing pathway
Glen Barber
4. Regulation of intracellular dsDNA-induced innate immune responses by autophagy-related proteins
Running title: Autophagy and dsDNA-induced innate immunity
Tatsuya Saitoh
5. Host DNA Induced Inflammation and Autoimmune Diseases
Surya Pandey, Taro Kawai
6. Systemic lupus erythematosus and the DNA sensing pathway
Ann Marshak-Rothstein
7. Bacterial infections and the DNA sensing pathway
Jan Naujoks, Bastian Opitz
8. Viral infections and the DNA sensing pathway: lessons from herpesviruses and beyond
Søren R. Paludan, Andrew G. Bowie
9. Cancer Pathogenesis and DNA sensing
Shen Y.J., Lam A.R., Ho S.S.W., Koo C.X., Le Bert N., Gasser S.
10. Atherosclerosis and Aging and DNA sensing
Moshe Arditi
11. DNA Vaccines: Does it Target the Double Stranded-DNA Sensing Pathway?
Cevayir Coban, Miyuki Tozuka, Nao Jounai, Kouji Kobiyama, Fumihiko Takeshita, Choon Kit Tang, Ken J. Ishii
12. Adjuvants targeting the DNA sensing pathways - Alum based adjuvants
Christophe J. Desmet
13. Adjuvants Targeting the DNA Sensing Pathways- Cyclic-di-GMP and Other Cyclic-di-Nucleotides
Rebecca Schmidt, Laurel L. Lenz
