Full Description
Regenerative Medicine Applications in Organ Transplantation illustrates exactly how these two fields are coming together and can benefit one another. It discusses technologies being developed, methods being implemented, and which of these are the most promising. The text encompasses tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, all from a transplant perspective. Organ systems considered include liver, renal, intestinal, pancreatic, and more. Leaders from both fields have contributed chapters, clearly illustrating that regenerative medicine and solid organ transplantation speak the same language and that both aim for similar medical outcomes. The overall theme of the book is to provide insight into the synergy between organ transplantation and regenerative medicine.
Recent groundbreaking achievements in regenerative medicine have received unprecedented coverage by the media, fueling interest and enthusiasm in transplant clinicians and researchers. Regenerative medicine is changing the premise of solid organ transplantation, requiring transplantation investigators to become familiar with regenerative medicine investigations that can be extremely relevant to their work. Similarly, regenerative medicine investigators need to be aware of the needs of the transplant field to bring these two fields together for greater results.
Contents
Meet the Editors
Preface
1. Introduction: Regenerative medicine and solid organ transplantation from a historical perspective
2. Solid organ transplantation: has the promise been kept and the needs met?
Principles of Regenerative Medicine and Cell, Tissue, and Organ Bioengineering
3. Strategies for the specification of tissue engineering biomaterials
4. Principles of Stem Cell Biology
5. Principles of cell sheet technology
6. Principles of bioprinting technology
7. Synthetic biomaterial for regenerative medicine applications
8. Natural biomaterials for regenerative medicine applications
9. Bioartificial biomaterials for regenerative medicine applications
10. Bioactivated materials for cell and tissue guidance
11. Biocompatibility and immune response to biomaterials
12. Harnessing regenerative and immunomodulatory properties of stem cells
13. Bioreactors for tissue engineering purposes
Kidney
14. Current status of renal transplantation
15. Living related renal transplantation: progress, pitfalls and promise
16. Machine perfusion of kidneys donated after cardiac death: the Carrel and Lindbergh legacy
17. Renal regeneration: the bioengineering approach
18. Renal regeneration: the stem cell biology approach
19. Renal regeneration: the developmental approach
Liver
20. Current status of liver transplantation
21. Living related liver transplantation: progress, pitfalls and promise
22. Donation after cardiac death liver transplantation
23. Artificial liver support
24. Liver regeneration: the bioengineering approach
25. Liver regeneration: the developmental biology approach
26. Liver regeneration: the stem cell approach
27. Liver bioengineering using human cells
Heart
28. Current status of heart transplantation
29. Artificial heart support
30. Heart regeneration: the bioengineering approach
31. Heart regeneration: the developmental and stem cell biology approach
Small Bowel
32. Current status of intestinal transplantation
33. Living related small bowel transplantation: progress, pitfalls and promise
34. Intestinal regeneration: the bioengineering approach
35. Intestinal regeneration: the developmental biology approach
36. Intestinal regeneration: stem cell approach
37. Building blocks for engineering the small intestine
Endocrine pancreas and islets of Langerhans
38. Current status of pancreas transplantation
39. Living related pancreas transplantation: progress, pitfalls and promise
40. Current status of islet transplantation
41. Pancreatic islets regeneration: the bioengineering approach
42. Pancreatic islet regeneration: the developmental and stem cell biology approach
43. Microencapsulation technology
44. Autologous islets transplantation
Lung
45. Current status of lung transplantation
46. Living related lung transplantation: progress, pitfalls and promise
47. Artificial Lung Support
48. Lung regeneration: the bioengineering approach
49. Lung regeneration: the developmental biology approach
50. Lung regeneration: stem cell approach
Composite tissues allotransplantation
Immunosuppression-free transplantation in the regenerative medicine era
Epilogue: Organ Bioengineering and Regeneration as the new Holy Grail of Organ Transplantation
