Full Description
In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors. The chapters cover a large breadth of research, including GPCR role in stem cell function and pharmacology.
Authors explore in-depth research techniques and applications of GPCR usage, covering theory, laboratory approaches, and unique qualities that make GPCRs a crucial tool in microbiological and cancer research.
Contents
Approaches for Probing Allosteric Interactions at 7 Transmembrane Spanning Receptors
Michael T. Klein, Paige N. Vinson and Colleen M. Niswender
Pharmacology of Metabotropic Glutamate Receptor Allosteric Modulators: Structural Basis and Therapeutic Potential for CNS Disorders
Karen J. Gregory, Meredith J. Noetzel and Colleen M. Niswender
Mining the Potential of Label-Free Biosensors for Seven-Transmembrane Receptor Drug Discovery
Magalie Rochville, Julio Martin, Jeffrey Clifford Jerman & Evi Kostenis
G Protein-Coupled Receptors in Cancer : Biochemical Interactions and Drug Design
Yves Audigier, François-Xavier Picault, Carline Chaves-Almagro and Bernard Masri
GPCRs in Stem Cell Function
Van A. Doze and Dianne M. Perez
Application of Receptor Theory to Allosteric Modulation of Receptors
David A. Hall
What Ligand-Gated Ion Channels Can Tell Us about the Allosteric Regulation of G protein-Coupled Receptors
Frederick J. Ehlert
Modelling Cooperativity Effects in Dimeric G Protein-Coupled Receptors
Jesús Giraldo
Chemokine Receptor Oligomerization and Allostery
Bryan Stephens and Tracy M. Handel
Fine-Tuning of GPCR Signals by Intracellular G Protein Modulators
Peishen Zhao, Wendy Cladman, Hubert HM Van Tol and Peter Chidiac
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