基本説明
A practical reference on pharmacogenomics that provides perspectives of the scientific and translational challenges and potential of molecular medicine.
Full Description
Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field forward. Clinical pearls and case studies are used to illustrate real-life experiences and both successful and unsuccessful applications. Tables, figures, and annotations are included throughout the book to facilitate understanding and further reference.
Contents
SECTION 1
1 Principles of Pharmacogenomics: Pharmacokinetic, Pharmacodynamic, and Clinical Implications
2 Translating Pharmacogenomic Research to Therapeutic Potentials
3 Governmental and Academic Efforts to Advance the Field of Pharmacogenomics (PGRN CPIC, PharmGKB)
Section 2
4a Pharmacogenomics in Cancer Therapeutics
4b A Look to the Future: Cancer epigenetics
5a Pharmacogenomics in Cardiovascular Diseases
5b A Look to the Future: Cardiovascular Pharmaco-epigenetics
6a Pharmacogenomics in Psychiatry Disorders
6b A Look to the Future: Epigenetics in psychiatric disorders and treatment
7 Role of Pharmacogenomics in Diabetes and Other Therapeutic Areas
SECTION 3
8a Molecular Approaches, Models, and Techniques in Pharmacogenomic Research and Development
8b Molecular Approaches, Models, and Techniques in Pharmacogenomic Research and Development
9a Incorporating Pharmacogenomics in Drug Development
Part 1: Rational study designs for pharmacogenetic research and therapy - A perspective from academia
9b Incorporating Pharmacogenomics in Drug Development
Part 2: A perspective from industry
10 Ethnobridging and Pharmacogenomics
SECTION 4
11 Beyond ELSIs - Where to from here? From 'Regulator' to Anticipating and Shaping the Innovation Trajectory in Personalized Medicine
12 The Economics of Pharmacogenomics
SECTION 5
13 Integrating Genomics into Pharmacy Education and Practice: Pharmacogenomics is not enough
