Full Description
Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases. This volume of Methods in Ezymology is split into 2 parts and comprehensively covers the subject.
Contents
Analysis of Serpin Secretion, Misfolding and Surveilance in the Endoplasmic Reticulum
Shujuan Pan, Michael J. Iannotti and Richard N. Sifers
Serpin-Enzyme Receptors: Ldl Receptor Related Protein 1
Dudley K. Strickland, Selen Catania Muratoglu and Toni M. Antalis
The Role of Autophagy in Alpha-1-Antitrypsin Deficiency
Tunda Hidvegi, Amitava Mukherjee, Michael Ewing, Carolyn Kemp and David H. Perlmutter
Serpins and the Complement System
László Beinrohr, Thomas A. Murray-Rust, Leanne Dyksterhuis, Péter Závodszky, Péter Gál, Robert N. Pike and Lakshmi C. Wijeyewickrema
Use of Mouse Models to Study Plasminogen Activator Inhibitor-1
Paul J. Declerck, Ann Gils and Bart De Taeye
Plasminogen Activator Inhibitor Type 2: Still An Enigmatic Serpin But A Model For Gene Regulation
Robert L. Medcalf
The Serpinb1 Knock-Out Mouse: A Model For Studying Neutrophil Protease Regulation in Homeostasis and Inflammation
Charaf Benarafa
Investigating Maspin in Breast Cancer Progression Using Mouse Models
Michael P. Endsley and Ming Zhang
Hsp47as A Collagen-Specific Molecular Chaperone
Yoshihito Ishida and Kazuhiro Nagata
Assays for the Antiangiogenic and Neurotrophic Serpin Pigment Epithelium-Derived Factor
S. Patricia Becerra, Susan E. Crawford and Preeti Subramanian
The Drosophila Serpins: Multiple Functions in Immunity and Morphogenesis
Jean Marc Reichhart, David Gubb and Vincent Leclerc
Modelling Serpin Conformational Diseases in Drosophila Melanogaster
Thomas R. Jahn, Elke Malzer, John Roote, Anastasia Vishnivetskaya, Sara Imarisio, Maria Giannakou, Karin Panser, Stefan Marciniak, Damian C. Crowther
Using Caenorhabditis Elegans to Study Serpinopathies
Olivia S. Long, Sager J. Gosai, Joon Hyeok Kwak, Dale E. King, David H. Perlmutter, Gary A. Silverman and Stephen C. Pak
Using c. Elegans to Identify the Protease Targets of Serpins In Vivo.
Sangeeta R. Bhatia, Mark T. Miedel, Cavita K. Chotoo, Nathan J. Graf, Brian L. Hood, Thomas P. Conrads, Gary A. Silverman and Cliff J. Luke
Viral Serpin Therapeutics: From Concept to Clinic
Hao Chen, MD, PhD, Donghang Zheng, MD, PhD, Jennifer Davids, BA, Mee Yong Bartee, PhD, Erbin Dai, MD, Liying Liu, MD, Lyubomir Petrov, MD, PhD, Colin Macaulay, PhD, Robert Thoburn, MD, Eric Sobel, MD, PhD, Richard Moyer, PhD, Grant McFadden, PhD, Alexandra Lucas, MD, FRCP(C)
Human Scca Serpins Inhibit Staphylococcal Cysteine Proteases by Forming Classic "Serpin-Like" Covalent Complexes
Tomasz Kantyka and Jan Potempa
Plants and the Study of Serpin Biology
Thomas H. Roberts, Joon-Woo Ahn, Nardy Lampl and Robert Fluhr
