基本説明
腎臓病の基礎および臨床研究の最も優れた代表的レファレンス、５年ぶりの新版。腎臓学の基礎研究成果を包括的に網羅し、腎臓機能と機能障害に関して分子生物学的・細胞生理学から臨床にいたるまでの最新の治験を収録する。
4th ed.: 2007.
Full Description
A classic nephrology reference for over 25years, Seldin and Giebisch's The Kidney, is the acknowledged authority on renal physiology and pathophysiology. In this 5th edition, such new and powerful disciplines as genetics and cell biology have been deployed to deepen and widen further the explanatory framework. Not only have previous chapters been extensively updated, but new chapters have been added to incorporate additional disciplines. Individual chapters, for example, now provide detailed treatment of the significance of cilia; the role of stem cells is now given special consideration. Finally, there has been a significant expansion of the section of pathophysiology, incorporating the newer findings of cell biology and genetics. If you research the development of normal renal function or the mechanisms underlying renal disease, Seldin and Giebisch's The Kidney is your number one source for information.
Contents
Section 1: Epithelial and Nonepithelial Transport and Regulation
1 Epithelial Cell Structure and Polarity
Michael Caplan
2 Mechanisms of Ion Transport Across Cell Membranes & Epithelia
Luis Reuss and Guillermo Altenberg
3 Renal Ion-Translocating AT Phases: The P-Type Family
Eric Feraille
4 Mechanisms of Water Transport Across Cell Membranes & Epithelia
Luis Reuss and Guillermo Altenberg
5 Cell Volume Control
Florian Lang
6 Soute Transport, Energy Consumption, and Production in the Kidney
Hitoshi Endou and Takashi Sekine
7 Electrophysiological Analysis of Transepithelial Transport
Lawrence G. Palmer and Henry Sackin
8 Ion Channels and Electro-physiological Properties of Transport
James Stockand
9 Exchange of Fluid and Solutes Across Microvascular Walls
C. Charles Michel
10 External Balance of Electrolytes and Acids and Alkali
Man S. Oh
11 Cilium
Bradley Yoder
12 Inter-cellular Junctions
Alan S. L. Yu, Jano Peti-Perterdi, Fiona Hanner
13 Principles of Cell Signaling
Lloyd Cantley
14 Scaffolding Proteins in Transport Regulation
Paul A. Welling
15 The Renin-Angiotensin System
Thomas M. Coffman
16 Neural Control of Renal Function
Ulla C. Kopp and EJ Johns
17 Eicosanoids and the Kidney
Matthew Breyer, Raymond C. Harris, Richard M. Breyer
18 Extracellular Nucleotides and Renal Function
Robert J. Unwin and David Shirley
19 Paracrine Regulation of Renal Function by Dopamine
Pedro Jose
Section 2: Structural and Functional Organization of the Kidney
20 Structural Organization of the Mammalian Kidney
Wilhelm Kriz and Brigitte Kaissling
21 Biophysical Basis of Glomerular Filtration
Roland C. Blantz and Scott Thomson
22 Glomerular Structure and Cell Biology
Susan Quaggin
23 Function of the Juxtaglomerular Apparatus
Jurgen Schnermann and Hayo Castrop
24 Renal Cortical & Medullary Microcirculations
Thomas L. Pallone
25 Molecular and Cellular Mechanisms of Kidney Development
Sanjay K. Nigam and Kevin T. Bush
26 Molecular and Cellular Mechanisms of Glomerular Capilary Development
Jeffrey H. Miner and Dale R. Abrahamson
27 Postnatal Renal Development
Michael Baum
28 Renal Hyperplasia and Hypertrophy
Stuart J. Shankland
29 Stem Cells
Qais Al-Awqati and Juan Oliver
Section 3: Fluid and Electrolyte Regulation and Dysregulation
30 Epithelial Na+ Channels
Thomas R. Kleyman
31 Anion Channels
William B. Guggino
32 NaCL Co-transporters
Gerardo Gamba
33 Sodium and Chlorid Transport
Alan M. Weinstein
34 Sodium Chloride Transport in the Loop of Henle, Distal Convoluted Tubule, and Collecting Duct Gerardo Gamba and Laurent Schild
35 Mineralocorticoid Action in the Aldosterone-Sensitive Distal Nephron
Johannes Loffing and Oliver Staub
36 Inherited Disorders of Renal Salt Homeostasis: Insights From Molecular Genetics Studies
Rick Lifton
37 Natriuretic Hormones
David L. Vesely
38 Physiology & Pathophysiology of Sodium Retention and Wastage
Biff F. Palmer, Donald W. Seldin and Robert J. Alpern
39 Physiology of Hypertension
John E. Hall
40 Physiology & Pathophysiology of Diuretic Action
David H. Ellison
41 Aquaporin Water Channels in Mammalian Kidney
Soren Nielsen
42 Thirst and Vasopressin
Gary L. Robertson
43 The Urine Concentrating Mechanism and Urea Transporters
Jeff M. Sands and Harold Layton
44 Hyponatremia
Richard H. Sterns
45 Hypernatremic States
Laurence Chan and Chris Rivard
46 Polyuria and Diabetes Insipidus
Daniel G. Bichet
47 The Molecular Biology of Renal Potassium Channels
Wenhui Wang and Chou Long Huang
48 Extrarenal Potassium Metabolism
Robert M. Rosa
49 Regulation of Potassium Excretion
Gerhard Giebisch and Lisa Satlin
50 Potassium Deficiency
Giovambattista Capasso, Miriam Zacchia and Francesco Trepiccione
51 Clinical Disorders of Hyperkalemia
Mitchell Halperin and Kamel
52 Control of Intracellular pH
Walter F. Boron and Mark Bevensee
53 Sodium-Coupled Bicarbonate Transporters
Ira Kurtz
54 The SLC4 Anion Exchanger Gene Family
Seth Alper
55 Cellular Mechanisms of Renal Tubular Acidification
Patricia Preisig, L. Lee Hamm and Robert Alpern
56 Chemoreceptors, Breathing, and pH
Eugene Nattie
57 Renal Ammonium Ion Production and Excretion
Norman P. Curthoys
58 Clinical Syndromes of Metabolic Alkalosis
Orson Moe, Robert J. Alpern and Donald W. Seldin
59 Clinical Syndromes of Metabolic Acidosis
Reto Krapf, Donald W. Seldin and Robert J. Alpern
60 Respiratory Alkalosis and Acidosis
Horacio J Adrogue and Nicolaos Madias
61 Mechanisms and Disorders of Magnesium Metabolism
Karl P. Schlingmann and Martin Konrad
62 Calcium Channels
René J.M. Bindels and Joost Hoenderop
63 The Calcium-Sensing Receptor
Edward Brown
64 Renal Calcium Metabolism
Peter A. Friedman and Jose Bernardo
65 The Hormonal Regulation of Calcium Metabolism
Rajiv Kumar
66 Disorders of Calcium Metabolism
John Wysolmerski and Cristina Dumitru
67 Pathogenesis and Treatment of Nephrolithiasis
Fredric L. Coe, Elaine Worcester and Andrew Evan
68 Proximal Tubular Handling of Phosphate
Heini Murer, Jurg Biber, Nati Hernando, and Ian Forster
69 Clinical Disturbances of Phosphate Homeostasis
Rajiv Kumar
70 Glucose Reabsorption in the Kidney
Ernest M. Wright
71 Amino Acids, Oligopeptides, and Hyperaminoacidurias
Francois Verrey, Simone R. Camargo, Victoria Makrides, Robert Kleta
72 Organic Anion and Cation Transporters in Renal Elimination of Drugs
Gerhard Burckhardt and Herman Koepsell
73 Renal Filtration, Transport, and Metabolism of Albumin and Albuminuria
Erik I. Christensen, Rikke Nielsen, Henrik Birn
Section 4: Pathophysiology of Renal Disease
74 Physiologic Principles in the Clinical Evaluation of Electrolyte, Water, and Acid-Base Disorders Daniel Batlle
75 Biomarkers of Assessment of Renal Function (AKI/CKD)
Prasad Devarajan
76 Pathophysiology of Acute Kidney Injury
Bruce A Molitoris and Asif Sharfuddin
77 Ischemic Renal Disease
William L. Henrich, Lance Dworkin, and Christopher Cooper
78 Pathophysiology and Pathogenesis of Diabetic Nephropathy
Fuad N. Ziyadeh
79 Renal Failure in Cirrhosis
Robert W. Schrier and Pere Gines
80 Autosomal Dominant Polycystic Kidney Disease and Inherited Cystic Diseases
Stefan Somlo
81 Renal Physiology and Disease in Pregnancy
Ananth Karunmanchi
82 Immune-Mediated and Other Glomerular Diseases
John R. Sedor and Mike Madaio
83 Immunologic Mechanisms of Vasculitis
J. Charles Jennette, Jonathan Homeister, Ronald J. Falk
84 Genetic Abnormalities in Glomerular Function
Clifford E Kashtan and Yoav Segal
85 Cellular Mechanisms of Drug Nephrotoxicity
Zoltán Huba Endre and Robert Walker
86 Role of Glomerular Pressure in Progression
Roberto Zatz
87 Role of Protinuria in Progression
Giuseppe Remuzzi
88 The Inflammatory Response to Ischemic Acute Renal Injury
Christopher Y. Lu
89 Oxidants in Progressive Kidney Disease
Sudhir Vithalbhai Shah
90 Chronic Kidney Disease
William E. Mitch
91 Mineral Metabolism and Bone
L. Darryl Quarles
92 Hematopoiesis and the Kidney
Armin Kurtz
93 Electrolyte Disturbances in Dialysis
Biff Palmer
94 Homeostasis of Solute and Water by the Transplanted Kidney
J. Harold Helderman
95 Disposition and Dose Requirements of Drugs in renal Insufficiency
D. Craig Brater, Kathleen Giacomini, Claire Weiss, Par Matsson
